Towards a new pharmacotherapy of pain : report of the Dahlem Workshop on Towards a New Pharmacotherapy of Pain: Beyond Morphine, Berlin, 1989, November 12-17
著者
書誌事項
Towards a new pharmacotherapy of pain : report of the Dahlem Workshop on Towards a New Pharmacotherapy of Pain: Beyond Morphine, Berlin, 1989, November 12-17
（Dahlem workshop reports）（Life sciences research report, 49）
John Wiley & Sons, 1991
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注記
"A Wiley-Interscience publication."
Includes bibliographical references and indexes
内容説明・目次
内容説明
Towards a New Pharmacotherapy of Pain A. I. Basbaum J. -M. Besson Editors Why are narcotics still the drug of choice for the treatment of severe pain? How useful are antagonists to Substance P, CGRP, bradykinin, and other putative nociceptive transmitters and inflammatory mediators? How can we use information about the multiplicity of opiate receptor families and opioid peptide classes to improve the action of opiates and to reduce unwanted side-effects? How prevalent is tolerance to narcotics and what mechanisms underlie its development? What is the basis for neuropathic pains that makes them less responsive to narcotics? In this volume pain clinicians, pharmacologists, neurobiologists, and molecular biologists address these and other questions and provide a comprehensive discussion of practical approaches to developing a new pharmacotherapy of pain. The book will appeal to all basic scientists and clinicians interested in the problem of pain and its control.
目次
Partial table of contents: What Peripheral Mechanisms Contribute to Nociceptive Transmission and Hyperalgesia? (H. Handwerker). The Contribution of Monoamines and Their Receptors to Pain Control (M. Hamon, et al.). Molecular and Cellular Mechanisms of Opioid Tolerance (B. Cox). Clinical Tolerance to Opioids (K. Foley). Opioid Receptor Types and Subtypes: Relevance to Function and Drug Design (R. Przewlocki). Factors Contributing to the Control of Sympathetic Nervous Activity (K. Dembowsky). Nerve Growth Factor: A Signaling Protein Between the Nervous and the Immune Systems (U. Otten). Issues in the Management of Neuropathic Pain (R. Portenoy). List of Participants with Fields of Research. Subject Index. Author Index.
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