Peptide drug delivery to the brain
著者
書誌事項
Peptide drug delivery to the brain
Raven Press, c1991
大学図書館所蔵 全12件
注記
Includes bibliographical references and index
内容説明・目次
内容説明
This discusses new and established strategies for delivering peptides and antibodies through the blood-brain barrier. It reviews concepts on blood-brain barrier transport biology, assesses the utility and limitations of traditional brain drug delivery methods and describes new drug delivery techniques. The opening section of the book presents a review of neuropeptide biology and the potential of clinical applications of neuropeptides. Next comes information on the principles of blood-brain barrier transport physiology and cell biology. Attention is given to the problems involved in developing blood-brain barrier transport vectors that are capable of shuttling neuropeptides or monoclonal antibodies across the blood-brain barrier and into specific areas of the brain. Subsequent chapters review existing modalities for drug delivery to the brain including neurosurgical-based and pharmacologic-based strategies. The second half of the book focuses on strategies for blood-brain barrier delivery of peptides, antibodies and other neuropharmacuticals.
These include methods for : receptor-mediated and absorptive mediated transcytosis of peptides and antibodies through the blood-brain barrier; delivery of chimeric peptide neuropharmaceuticals through the blood-brain barrier via chemical linkers, avidin-based linkers and peptide linkers formed in gene fusions; and molecular biological strategies for the development of brain-specific transport vectors. Some 900 citations are lised, many from papers published in 1990.
目次
- Biological diversity of peptides
- peptides as potential neuropharmaceuticals in disorders of the brain
- overview of blood-brain barrier transport biology and experimental methodologies
- transnasal and intraventricular delivery of drugs
- peptide lipidization and liposomes
- bulk flow and receptor-mediated transcytosis of peptides through the blood-brain barrier
- absorptive-mediated transcytosis of peptides through the blood-brain barrier
- antibody delivery through the blood-brain barrier
- chimeric peptide pharmaceutical delivery through the blood-brain barrier
- development of brain-specific transport vectors - a molecular biological perspective.
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