Fertilization of the human egg in vitro : biological basis and clinical application
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Fertilization of the human egg in vitro : biological basis and clinical application
Springer-Verlag, 1983
- : Germany
- : United States
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Cataloging based on CIP information
"Proceedings of a symposium sponsored by Organon GmbH, Germany, held at Murnau, near Munich, Federal Republic of Germany, June 2-4, 1982"--T.p. verso
Includes bibliographical references and index
内容説明・目次
内容説明
The Organon Symposia have actually become a tradition, keeping up with exciting developments in reproductive medicine. The purpose of this symposium on "Fertiliza- tion of the Human Egg in Vitro" was to bring together the stilllimited number of elinical specialists in the field and to stimulate another group of basic research people to exchange their experiences and knowledge, hopefully promoting elose cooperation between the two groups. It was a kind of scientific "first" that all research teams so far successful in achieving the birth of a healthy baby, fertilized in vitro came together at a workshop conference without a large audience of spectators and reporters, but with a small number of highly critical colleagues from the fields of basic reproductive physiology and comparative developmental biology. This atmosphere allowed for the elose exchange of results, hypotheses, diagnostic and therapeutic procedures, criticism, and respect, and created very productive discussions, all of which furthered the aim of the method: To help more childless couples to have their own babies by the ultima ratio procedure of in vitro fertilization and embryo replacement.
The book that has emerged from this symposium will help to disseminate the great amount of information and experience gathered among the scientifically and clinically interested colleagues of many other hospitals and universities who could not be invited to the meeting. At the same time, it will prove that there is much more work to be done in the basic and clinical sciences of human embryology and reproductive biology.
目次
- I. Follicle and Ovum Maturation.- Control of the Development of Meiotic Competence of Oocyte Maturation in Mammals.- The Preovulatory Human Oocyte and its Microenvironment.- Cytoplasmic Changes in Mammalian Oocytes During the Preovulatory Period.- Selection and Maturation of the Dominant Follicle and Its Ovum in the Menstrual Cycle.- II. Preparation of Patient and Timing of Oocyte Collection.- Influence of Ovarian Stimulation on Follicular Fluid Steroid Levels and Fertilizability of the Oocyte.- Ultrasound Diagnosis of Follicle Growth and Ovulation.- Hormonal and Ultrasonic Monitoring of Follicular Development and Ultrasound-guided Follicular Puncture.- Collection of Human Eggs for In Vitro Fertilization.- Monitoring of Follicular Development in Gonadotropin Stimulated Cycles.- The Use of Clomid and hMG in Human In Vitro Fertilization: Consequences for Egg Quality and Luteal Phase Adequacy.- III. Structures and Fertilizing Ability of Spermatozoa.- Form and Function of Eutherian Spermatozoa in Relation of the Nature of Egg Vestments.- Methods for Assessing the Functional Capacity of Human Spermatozoa
- Their Role in the Selection of Patients for In Vitro Fertilization.- IV. In Vitro Fertilization and Embryo Culture.- In Vitro Fertilization of Human Eggs: Analysis of Follicular Growth, Ovulation and Fertilization.- The Fine Structure of Normal and Abnormal Human Embryos Developed in Culture.- Evaluation of Normal and Abnormal Human Embryo Development During Procedures In Vitro.- Influence of Follicular Volume and Oocyte Maturity on the Fertilization Rate of Human Oocytes.- V. Embryo Transfer and Intrauterine Development.- Factors Controlling Normal Embryo Development and Implantation of Human Oocytes Fertilized In Vitro.- In Vitro Fertilization of Human Oocytes: Factors Associated with Embryonic Development In Vitro, Replacement of Embryos and Pregnancy.- Current Status of an In Vitro Fertilization Programme and Early Pregnancy Diagnosis.- Transfer of Human Embryos at Early Cleavage Stages.- Factors Influencing Ovo-Implantation and Maintenance of Pregnancy Following Embryo Transfer.- Hormones and Proteins Involved in Uterine Preparation for Implantation.- Early Hormone Parameters and Embryonic Development in Pregnancies Established by In Vitro Fertilization and Embryo Transfer.- VI. Animal Models for Egg Transfer and Embryo-Maternal Interactions.- Field Trials with Cryopreserved Bovine Embryos.- The Developmental Potential and Regulatory Capacity of Blastomeres from Two-, Four-, and Eight-Cell Sheep Embryos.- Nonhuman Primate Models for Egg Transfer.- Growth and Differentiation of Rabbit Blastocysts in Defined Culture Media.- Synthetic Capabilities of the Preimplantation Conceptus and Maternal Responses to Pregnancy.- VII. Aspects of Medical Jurisprudence.- The Legal Situation in the Federal Republic of Germany Regarding In Vitro Fertilization of the Human Egg.
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