Molecular biology of atherosclerosis : proceedings of the Twentieth Steenbock Symposium, held June 3 through June 5, 1990 at the University of Wisconsin--Madison, Madison, Wisconsin, U.S.A.

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Molecular biology of atherosclerosis : proceedings of the Twentieth Steenbock Symposium, held June 3 through June 5, 1990 at the University of Wisconsin--Madison, Madison, Wisconsin, U.S.A.

edited by Alan D. Attie

Elsevier, c1990

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

The eclectic array of papers in Molecular Biology of Atherosclerosis reflects the expansion of atherosclerosis investigation into many new areas of biology. Based on the Steenbock Symposium on Molecular Biology of Atherosclerosis, this proceedings volume brings together 136 researchers with expertise in the studies of nucleic acids, lipids, proteins, whole cells, and whole animals. Topics include: practical and theoretical aspects of gene expression, including regulatory elements and the use of keratinocytes; RNA metabolism, such as post-transcriptional editing of apo-B mRNA, post-translational processing of newly synthesised proteins, the mechanisms of protein translocation, and mutations affecting HDL levels; and apolipoprotein structure, metabolism, and growth control, covering modifications of LDL in relation to arterial wall metabolism, platelet-derived growth factor receptors, and changes in lipid metabolism in response to the ras-oncogene.

目次

Transcriptional and Post-Transcriptional Regulation. Independent regulatory elements control expression of the human apolipoprotein E. gene in the liver and kidney of transgenic mice. Expression of transfected apolipoprotein E by human squamous carcinoma cells. Heterologous expression of apolipoproteins. Prenyltransferases: from yeast to man. Analysis of intermediates in protein translocation across the endoplasmic reticulum. Molecular genetic analysis of vesicle formation in protein transport from the endoplasmic reticulum. Organ-specific variations on the Mechanism of protein topogenesis: two examples from brain and liver. Regulation of VLDL assembly and secretion. An LPL-receptor on adipocytes regulates LPL degradation. The editing of apolipoprotein-B mRNA. Regulation of c-myc mRNA stability in cells of cell-free extracts. Regulated degradation of apolipoprotein II mRNA. Animal Models. Size and composition of high-density lipoproteins is determined by a polymorphism affecting apolipoprotein A-II translational efficiency. Apolipoprotein-A1 translational efficiency. Apolipoprotein-A1 metabolism in WHAM chickens. Nutritional regulation of artherosclerosis and hepatic lipoprotein metabolism in primates. Apolipoprotein Structure. The crystal structure of a lipoprotein: lipovitellin. Structure studies of lipid binding proteins. Role of ampathic hexiles in HDL structure/function. Investigation of lysine residues in apolipoprotein B100 by NMR. Secondary structure of the Exon 3 encoded portion of apolipoprotein E. Arterial Wall, Cell Growth. The effect of minimally modified low-density lipoprotein on the expression of cytokines and adhesion molecules in Endothelial Cells. Role of LDL oxidation in foam cell formation and atherogenesis. The role of apolipoprotein(a) in atherosclerosis. Neutral lipid accumulation accompanies ras-oncogene induced growth arrest in a smooth muscle-like cell line. FDGF receptors: what? where? why? Characterization of a non-tyrosine kinase FGF-binding protein.

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