Human pharmacology : the basis of clinical pharmacology
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Bibliographic Information
Human pharmacology : the basis of clinical pharmacology
Elsevier , Sole distributors for the USA and Canada, Elsevier Science Pub. Co., 1991
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Includes bibliographical references and index
Description and Table of Contents
Description
Pharmacology is the science of the action of drugs on the body and incorporates all aspects, from conception, synthesis and effects of drugs to the eventual use in humans. In the initial stages of conception, animal models and cellular models in vitro are utilized to form a hypothesis about the benefits of a drug before clinical trials. This next stage of clinical pharmacology is pivotal as it will validate what was previously conjecture, but the risks taken must be more limited because human beings are involved. The most sophisticated methods of measurement and analysis are utilized at this stage to achieve maximum information with a minimal number of samples. The intention of Human Pharmacology is to examine the "state of the art" techniques of analysis and measurement of drug concentration in an organism, and of pharmacokinetic methods and their interpretation. Firstly, the work identifies the chemical species of the drug and its metabolites by analysis of biotransformations, and sequential quantification of the active forms of the drug and/or its metabolites in order to evaluate their kinetic parameters.
The second part of the book examines the fate of drugs in the body, different ways of interpreting and using pharmacokinetic data and bed-side adjustment of drug dosage regimens. Achievement of results however, must be obtained under rigorously controlled conditions according to stringent internationally recognized criteria. A special chapter is devoted to "good laboratory practices". This book is intended for non-specialists or students meaning to follow a career in pharmacology, but it will also prove to be of interest to the specialist in practice having been written by recognized specialists in many fields.
Table of Contents
Contents: Foreword (T. Shibuya and J.P. Tillement) I. Analytical Part. REQUIREMENTS FOR PHARMACOKINETIC STUDIES 1. General principles of analytical methodology in clinical pharmacology (G. Houin). 2. Good laboratory practice (J. Barre and J.C. Duche). DRUG AND METABOLITES IDENTIFICATION 3. Biotransformation: Analytical methodology (H.P. Koch). PHYSICOCHEMICAL METHODS IN DRUG ASSAY 4. Fluorometry-luminometry (C. Dreux). 5. Spectrophotometrical methods (B. Gourmel, P. Lefebvre and C. Dreux). 6. Automation of drug measurement in biological fluids (J.P. Garnier). 7. Polarographic and electrochemical methods (J.C. Vire, G.J. Patriarche and J.M. Kauffmann). 8. Mass spectrometry in drug studies (J.P. Monti and C. Aubert). 9. Isothermal microcalorimetry as a tool for the pharmacologist (J.C. Sari and C. Briand). OTHER METHODS IN DRUG ASSAY 10. Immunological assay of drugs (J. Barre). 11. Microbiological methods in testing antibiotics (J.D. Williams and F. Moosdeen). PLASMA DRUG-PROTEIN INTERACTIONS 12. Methods in drug protein binding analysis (R. Zini). ASSESSMENT OF DRUG EFFECTS: NEW PERSPECTIVES 13. Nuclear magnetic resonance: A new tool in basic, cellular and human pharmacology (J. Vion-Dury, S. Confort-Gouny and P.J. Cozzonne). II. Clinical. PHARMACOKINETICS 14. Basic clinical pharmcokinetics (T. Deutsch, E. Ludwig, H. Graber, J. Barre and G. Houin). INDEX
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