Lesions of primary afferent fibers as a tool for the study of clinical pain : proceedings of the International Symposium on Lesions of Primary Afferent Fibers as a Tool for the Study of Clinical Pain?, held in Rouffach, France, 9-13 June 1991
著者
書誌事項
Lesions of primary afferent fibers as a tool for the study of clinical pain : proceedings of the International Symposium on Lesions of Primary Afferent Fibers as a Tool for the Study of Clinical Pain?, held in Rouffach, France, 9-13 June 1991
（International congress series, no. 981）
Excerpta Medica, 1991
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
Serotonin (5-HT), at the peripheral level, is known to be an algogen capable of directly or indirectly (via sensitization) activating nociceptive afferent fibers. This may provide a novel approach to the production of novel analgesic drugs since some serotonin antagonists, unable to cross the blood brain barrier, have been shown to have analgesic properties in a model of inflammatory pain in the rat. The central serotinin systems have been the subject of considerable research over the last twenty years, and it is hoped that the critical aspects arising from this book will be instrumental in refining the experimental protocols used in allowing the roles of serotonin in nociception to be unmasked.
目次
Effects of 5HT on nociceptors. H.O. Handwerker, P.W. Reeh and K.H. Steen. The potential use of 5HT antagonists as "peripheral analgesics". H. Ollat. The anatomy of ascending serotonergic pathways possibly involved in pain modulation. A.J. Beitz. Serotonin receptors and the modulation of pain. M. Hamon, E. Collin, D. Chantrel, G. Daval, D. Verge, S. Bourgoin and F. Cesselin. Serotonin and spinal dorsal horn neuronal circuitry. M.A. Ruda. 5-hydroxytryptamine and neuronal activity in the dorsal horn of the spinal cord. M.H.T. Roberts, A.R. Sizer and H. Rees. Release of serotonnin following brainsten stimulation: correlation with inhibition of nociceptive dorsal horn neurons. L.S. Sorkin, D.J. McAdoo and W.D. Willis. Diffuse Noxious Inhibitory Controls (DNIC) and serotonin (5-HT). D. Le Bars. Modifications in nociceptive reactivity following various serotonergic treatments: methodological difficulties. K. Hole, O.G. Berge, P.K. Eide, O.B. Fasmer, S. Hunskaar, A. Lund, J.H. Rosland and A. Tjolsen. Interactions between 5-HT and noradrenaline in analgesia. C. Post and T. Archer. 5-HT and stimulation produced analgesia. J.L. Oliveras. Serotonin and stress-induced analgesia. D.D. Kelly. Nociceptive and antinociceptive action of serotonergic agonists administered intrathecally. G.L. Wilcox and A.A. Alhaider. Central metabolism and release of serotonin in pain and analgesia. J. Weil-Fugazza. In vivo electrochemical studies related to nociception within the serotonergic raphe-spinal system. J.P. Rivot. Role of serotonergic systems in morphine-induced antinociception. D. L. Hammond. Characterization of the blockade of morphine-induced antinociception by an agonist action at 5-HT 1A receptors. M.J. Millan and F.C. Colpaert. Serotonin metabolites in the CSF of chronic pain patients. L. Von Knorring. Antidepressants and pain management. A. Eschalier. Painful peripheral neuropathies: mechanisma and treatment. R. Dubner and M.B. Max. INDEX OF AUTHORS.
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