Microdialysis in the neurosciences
著者
書誌事項
Microdialysis in the neurosciences
(Techniques in the behavioral and neural sciences, v. 7)
Elsevier, 1991
大学図書館所蔵 全15件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes bibliographical references and index
内容説明・目次
- 巻冊次
-
ISBN 9780444811943
内容説明
Until very recently most experimental studies on brain chemistry were conducted with postmortem tissue. However, because of shortcomings with postmortem methods and also the desire to directly relate neurochemistry to behavior, there has been a rapid growth of interest towards in vivo neurochemical methods. The recent availability of small diameter hollow dialysis fibres and very sensitive analytical techniques has made microdialysis practical for the routine measurement of many endogenous neurochemicals in vivo. With its adoption in the neurosciences as the preferred technique for in vivo sampling, microdialysis techniques provide the focus for this present volume. This book provides a single reference source for detailed methodological information on the conduct of microdialysis experiments for studying neurotransmitter dynamics in vivo. The emphasis is on practical considerations, and contributors have been encouraged to share their "tricks of the trade" to help other researchers quickly and easily adopt these methodologies in their own laboratories.
目次
Preface. List of Contributors. SECTION I: Introduction to Microdialysis. Introduction to intracerebral microdialysis (U. Ungerstedt). Microdialysis compared with other in vivo release models (B.H.C. Westerink, J.B. Justice, Jr.). SECTION II: Issues of Quantification. Quantitative microdialysis (P.F. Morrison et al.). Practical aspects of using microdialysis for determination of brain interstitial concentrations (H. Benveniste, A.J. Hansen). SECTION III: Methodological Considerations. Microdialysis and liquid chromatography (P.T. Kissinger). Procedures for microdialysis with smallbore HPLC (H.O. Pettit, J.B. Justice, Jr.). The use of microdialysis in pharmacokinetics and pharmacodynamics (L. Stahle). Brain dialysis of monoamines (G. Di Chiara). The feasibility of repeated microdialysis for within-subjects design experiments: studies on the mesostriatal dopamine system (T.E. Robinson, D.M. Camp). SECTION IV: The Application of Microdialysis in the Basic Neurosciences. A microdialysis and automated on-line analysis approach to study central cholinergic transmission in vivo (G. Damsma, B.H.C. Westerink). Monitoring extracellular norepinephrine in brain using in vivo microdialysis and HPLC-EC (E.D. Abercrombie, J.M. Finlay). Measurement of extracellular neuropeptides in the brain: microdialysis linked to solid phase radioimmunoassays with subfemtomole limits of detection (N.T. Maidment, C.J. Evans). Microdialysis for the study of hypothalamic and pituitary function (J.E. Levine et al). Microdialysis in large unrestrained animals: neuroendocrine and behavioral studies of acetylcholine, amino acid, monoamine and neuropeptide release in the sheep (K.M. Kendrick). On-line real-time monitoring of extracellular lactate, ethanol, glucose and choline using microdialysis and enzyme reactors (J. Korf et al.). Application of microdialysis to the study of motivation and conditioning: measurements of dopamine and serotonin in freely behaving rats (G.P. Mark et al). SECTION V: The Application of Microdialysis in the Clinical Neurosciences. Microdialysis for metabolic monitoring in cerebral ischemia and trauma: experimental and clinical studies (L. Hillered, L. Persson). Microdialysis techniques for studying brain amino acids in the extracellular fluid: basic and clinical studies (A. Hamberger et al.). In vivo neurochemistry of the conscious human brain: intrahippocampal microdialysis in epilepsy (M.J. During). Subject Index.
- 巻冊次
-
ISBN 9780444893758
内容説明
Until very recently most experimental studies on brain chemistry were conducted with postmortem tissue. However, because of shortcomings with postmortem methods and also the desire to directly relate neurochemistry to behavior, there has been a rapid growth of interest towards in vivo neurochemical methods. The recent availability of small diameter hollow dialysis fibres and very sensitive analytical techniques has made microdialysis practical for the routine measurement of many endogenous neurochemicals in vivo. With its adoption in the neurosciences as the preferred technique for in vivo sampling, microdialysis techniques provide the focus for this present volume. This book provides a single reference source for detailed methodological information on the conduct of microdialysis experiments for studying neurotransmitter dynamics in vivo. The emphasis is on practical considerations, and contributors have been encouraged to share their "tricks of the trade" to help other researchers quickly and easily adopt these methodologies in their own laboratories. A comprehensive overview of developments in microdialysis technology and allied analytical techniques is provided, both thought-provoking to experienced researchers, as well as a valuable aid to novices establishing these techniques for themselves.
目次
Preface. List of Contributors.
SECTION I: Introduction to Microdialysis.
Introduction to intracerebral microdialysis (U. Ungerstedt). Microdialysis compared with other in vivo release models (B.H.C. Westerink, J.B. Justice, Jr.).
SECTION II: Issues of Quantification.
Quantitative microdialysis (P.F. Morrison et al.). Practical aspects of using microdialysis for determination of brain interstitial concentrations (H. Benveniste, A.J. Hansen).
SECTION III: Methodological Considerations.
Microdialysis and liquid chromatography (P.T. Kissinger). Procedures for microdialysis with smallbore HPLC (H.O. Pettit, J.B. Justice, Jr.). The use of microdialysis in pharmacokinetics and pharmacodynamics (L. Stahle). Brain dialysis of monoamines (G. Di Chiara). The feasibility of repeated microdialysis for within-subjects design experiments: studies on the mesostriatal dopamine system (T.E. Robinson, D.M. Camp).
SECTION IV: The Application of Microdialysis in the Basic Neurosciences.
A microdialysis and automated on-line analysis approach to study central cholinergic transmission in vivo (G. Damsma, B.H.C. Westerink). Monitoring extracellular norepinephrine in brain using in vivo microdialysis and HPLC-EC (E.D. Abercrombie, J.M. Finlay). Measurement of extracellular neuropeptides in the brain: microdialysis linked to solid phase radioimmunoassays with subfemtomole limits of detection (N.T. Maidment, C.J. Evans). Microdialysis for the study of hypothalamic and pituitary function (J.E. Levine et al). Microdialysis in large unrestrained animals: neuroendocrine and behavioral studies of acetylcholine, amino acid, monoamine and neuropeptide release in the sheep (K.M. Kendrick). On-line real-time monitoring of extracellular lactate, ethanol, glucose and choline using microdialysis and enzyme reactors (J. Korf et al.). Application of microdialysis to the study of motivation and conditioning: measurements of dopamine and serotonin in freely behaving rats (G.P. Mark et al).
SECTION V: The Application of Microdialysis in the Clinical Neurosciences.
Microdialysis for metabolic monitoring in cerebral ischemia and trauma: experimental and clinical studies (L. Hillered, L. Persson). Microdialysis techniques for studying brain amino acids in the extracellular fluid: basic and clinical studies (A. Hamberger et al.). In vivo neurochemistry of the conscious human brain: intrahippocampal microdialysis in epilepsy (M.J. During).
Subject Index.
「Nielsen BookData」 より