Hypertension as an insulin-resistant disorder : genetic factors and cellular mechanisms : proceedings of the 5th Novo Nordisk Foundation Symposium "Hypertension as an insulin-resistant disorder. Genetic factors and cellular mechanisms," Copenhagen, Denmark, 1-3 July 1991
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書誌事項
Hypertension as an insulin-resistant disorder : genetic factors and cellular mechanisms : proceedings of the 5th Novo Nordisk Foundation Symposium "Hypertension as an insulin-resistant disorder. Genetic factors and cellular mechanisms," Copenhagen, Denmark, 1-3 July 1991
（International congress series, no. 980）（Novo Nordisk Foundation symposia, no. 5）
Excerpta Medica, 1991
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Includes bibliographical references and indexes
内容説明・目次
内容説明
It is generally agreed that primary hypertension is a multifactorial disorder where both genetic and environmemntal factors play an important role. In recent years it has become evident that hypertension is closely associated with a number of metabolic risk factors for cardiovascular disease. Insulin resistance and hyperinsulinemia seem to play a key role in the development of these risk factors. An increasing body of evidence also suggests that insulin may be directly involved in the pathogenesis of hypertension. Thus investigators representing different disciplines and approaches have critically reviewed the molecular and clinical evidence for the role of insulin in the pathogenesis of hypertension in this volume. Also suggested are possible interactions of insulin with genetic and environmental factors. This book succeeds in generating new approaches and defining areas needing further exploration, as well as contributing to the better understanding of the subject as a whole.
目次
Introductory Lecture. Primary Hypertension and Insulin Resistance - A Common Cause or a Causal Relationship? (B. Folkow). Hypertension - An Interplay Between Genes and the Environment. Hypertension in Animal Models: Key Genetic Factors at Molecular and Cellular Levels (D. Cusi, P. Stella, C. Robba, G. Bianchi). Interactions of Genetic and Environmental Factors at the Cellular Level in Human Hypertension (J.D. Swales). Psychological and Central Neuro-hormonal Influences in Primary Hypertension (B. Folkow). Insulin Resistance, Hyperinsulinemia, Hypertriglyceridemia and Hypertension: Existence in Patients and Rodent Models (G.M. Reaven). Interpretation of Genetic Versus Environmental Factors - Lessons from the Australian Aborigines when Westernized (K. O'Dea). Genes, Hypertension and Coronary Heart Disease: Evidence for Shared Metabolic Pathophysiology (R.R. Williams et al.). Discussion. The Role of Insulin in Hypertension. Hypertension as an Insulin Resistant Disorder: Role of Obesity (E. Ferrannini). Insulin as a Regulator of Sympathetic Nervous System Activity (L. Landsberg). A Common Cellular Pathway for Insulin Resistance in Essential Hypertension and NIDDM (N. Lasker, A. Aviv). Trophic Effects of Insulin and Other Growth Factors on the Vascular Wall (A.F. Lever, S. Griffin, F. MacPherson). Discussion. Molecular Basis of Insulin Resistance. Insulin Receptors and Actions on Vascular Walls (G.L. King et al.). Insulin Resistance - Defining the Problem at the Cellular Level (S. Cushman). The Insulin-antagonistic Effects of Catecholamines (P. Lonnroth). Is Insulin-resistance in Hypertension a Generalized Phenomena? (A.P. Rocchini). Calcium, Insulin Action and Insulin Resistance (B. Draznin et al.). Discussion. Is Insulin Resistance an Important Factor in Hypertension? Epidemiological Evidence for a Link Between Insulin Resistance, Hyperinsulinemia and Hypertension (M. Modan). Insulin Resistance as a Cause of Impaired Glucose Tolerance (C. Bogardus et al.). Dyslipidemia as an Insulin-resistant Disorder (A. Garg, S.M. Grundy). Insulin and the Fibrinolytic System. A Link Between Metabolism and Thrombogenesis (P. Vague, I. Juhan-Vague). Discussion. Treatment of Hypertension - Have we Forgotten Something? Effect of Current Treatment of Hypertension on Metabolism and Risk of Cardiovascular Disease (W.B. Kannel). Specific Pharmacological Treatment of Insulin Resistance - A Novel Approach in Hypertension and Dyslipidemia (K. Landin). Non-pharmacological Treatment of Hypertension - Effects and Limitations (B. Fagerberg). The Individualization of Antihypertensive Therapy by Risk Stratification and Selective Therapeutic Choice (J. Menard, M. Day, G. Bobrie, G. Chatellier). Discussion. Concluding Remarks. Insulin Resistance and Hypertension - A Relationship with Many Possibilities (U. Smith). Index of Authors. Subject Index.
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