Nucleoside analogues : chemistry, biology, and medical applications
Author(s)
Bibliographic Information
Nucleoside analogues : chemistry, biology, and medical applications
(NATO advanced study institutes series, Series A,
Plenum Press, c1979
Available at 13 libraries
  Aomori
  Iwate
  Miyagi
  Akita
  Yamagata
  Fukushima
  Ibaraki
  Tochigi
  Gunma
  Saitama
  Chiba
  Tokyo
  Kanagawa
  Niigata
  Toyama
  Ishikawa
  Fukui
  Yamanashi
  Nagano
  Gifu
  Shizuoka
  Aichi
  Mie
  Shiga
  Kyoto
  Osaka
  Hyogo
  Nara
  Wakayama
  Tottori
  Shimane
  Okayama
  Hiroshima
  Yamaguchi
  Tokushima
  Kagawa
  Ehime
  Kochi
  Fukuoka
  Saga
  Nagasaki
  Kumamoto
  Oita
  Miyazaki
  Kagoshima
  Okinawa
  Korea
  China
  Thailand
  United Kingdom
  Germany
  Switzerland
  France
  Belgium
  Netherlands
  Sweden
  Norway
  United States of America
Note
Lectures presented at the NATO Advanced Study Institute on Nucleoside Analogues, held at SOGESTA Centre, Urbino, Italy, May 7-18, 1979
Includes bibliographical references and index
Description and Table of Contents
Description
This publication contains the Review Lectures given at a joint NATO Advanced Study Institute and a FEB S Advanced Study Course, held at Sogesta (Nr. Urbino), Italy from the 7th - 18th May 1979. The Course entitled "Nucleoside Analogues : Chemistry, Biology and Medical Applications" was held for several reasons. In the past few years, many useful and potentially-useful nucleoside analogues have either reached the stage of clinical use or are undergoing clinical trials. Many more compounds have been synthesised by the organic chemist and little more has been done with them other than possibly a few perfunctory biological tests. This is often due to either a lack of interest or an inadequate knowledge of the testing proced- ures available or a lack of communication between the chemist, biochemist, pharmacologist and the clinician such that few compounds receive the testing and evaluation which they deserve.
The aim of this meeting was to gather together many of the experts in the different scientific disciplines which are involved in the design, synthesis, testing and clinical use of nucleoside analogues, primarily as anti-viral and anti-cancer agents, and to discuss in depth the fundamental principles of each discipline so that participants could understand each other's problems and be more aware of the information required and that which can be obtained.
Table of Contents
Nucleotide Conformations: Rules and Exceptions.- Nuclear Magnetic Resonance Studies of Nucleoside Conformational Properties.- Methods of Nucleoside Synthesis.- Chemical Transformations of the Sugar Moiety of Nucleosides.- Chemistry of Naturally Occurring Pyrimidine Nucleosides and Analogues.- Chemistry of the Heterocyclic Moiety of Purine Nucleosides and Some Closely Related Analogues.- The Mechanisms of Inhibition of Cellular and Viral Multiplication by Aranucleosides and Aranucleotides.- Uptake and Metabolism of Purine Nucleosides and Purine Nucleoside Analogues by Cells.- Basis for the Selective Antiviral and Antitumour Activity of Pyrimidine Nucleoside Analogues.- Development of Antiherpes Virus Agents on the Basis of Virus Induced Enzymes.- Test Systems for Evaluating the Antiviral Activity of Nucleoside Analogues.- Test Systems for Evaluating the Antitumour Activity of Nucleoside Analogues.- Success of Antiviral Therapy Involves Cooperative Immune Responses.- The Clinical Uses of Nucleoside Analogues in Malignant Disease.- Industrial Development of New Drugs.- Participants.
by "Nielsen BookData"