Pharmacology of the skin
Author(s)
Bibliographic Information
Pharmacology of the skin
（Pharmacology & toxicology）
CRC Press, 1992
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Note
Includes bibliographical references and index
Description and Table of Contents
Description
This book presents a balanced, state-of-the-art summary of pharmacology as it relates to the skin. Topics discussed include structure of the skin and its barrier function; model systems for research in skin pharmacology; the drug metabolizing capability of the skin, skin pharmacology in health and disease; the role of oxidants and antioxidants in the skin; immunopharmacology of the skin; signal transduction, protein kinase C and the role of the eicosanoid receptors in skin; and cutaneous chemical- and photo-carcinogenesis. Pharmacology of the Skin provides essential information for investigators working in cutaneous biology, investigative and clinical dermatologists, pharmacologists, pharmacists, biochemists, and workers in the pharmaceutical industry engaged in drug development.
Table of Contents
Skin and Its Barrier Function: The Structure and Function of Skin (R.L. Eckert). Percutaneous Absorption (R.O. Potts, D.B. Bommannan, and R.H. Guy). Role of Lipids in Barrier Function of the Skin (P.M. Elias). Skin Model System: Skin Xenografts and Their Utility in Pharmacological Research (G.G. Krueger and L.K. Pershing). Transdermal Drug Delivery Systems (P.W. Ledger, R. Gale, and S.I. Yum). Drug Metabolism in Skin: Cutaneous Metabolism of Xenobiotics and Steroid Hormones (H. Mukhtar, R. Agarwal, and D.R. Bickers). Cutaneous Metabolism During Percutaneous Absorption (S.W. Collier and R.L. Bronaugh). Cutaneous Glutathione S-Transferases (H. Raza, R. Agarwal, and H. Mukhtar). Cutaneous Cytochrome P-450 (H. Mukhtar). Skin Pharmacology in Health and Disease: Drug-Induced Skin Disorders (H.F. Merk, H. Mukhtar, and M. Hertl). Retinoid Pharmacology and Skin (B.A. Gilchrest). Vitamin D3: Synthesis and Biologic Functions in Skin (M.F. Holick and T.C. Chen). Pharmacology of the Aging Skin (G.F. Webster and J.J. Uitto). Pharmacology of Psoralen Photochemotherapy (D.R. Bickers and H. Mukhtar). Oxidants and Antioxidants in Skin. Sunscreens: Principles of Photoprotection (M.A. Pathak). Antioxidants in the Skin (J. Fuchs, H.-J. Freisleben, and L. Packer). Role of Reactive Oxygen Species in Skin (M. Athar, R. Agarwal, D.R. Bickers, and H. Mukhtar). Immunopharmacology of the Skin: Pharmacology of Cytokines in the Skin (T. Schwarz and T.A. Luger). Therapeutical Aspects of ICAM-1 Regulation in the Skin (J. Krutmann). Signal Transduction and Eicosanoid Receptor in Skin: Epidermal Eicosanoid Receptors (E. Gross and T. Ruzicka). Significance of Inositol Phospholipid Metabolism/Signal Transduction in the Skin (V.A. Ziboh and W. Tang). Biochemical Pharmacology of Protein Kinase C and Its Relevance for Dermatology (L. Hagemann and G. Mahrle). Skin Carcinogenesis: Cutaneous Chemical Carcinogenesis (R. Agarwal and H. Mukhtar). Cutaneous Photocarcinogenesis (C.A. Elmets). Index.
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