Frontiers in bioprocessing

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Bibliographic Information

Frontiers in bioprocessing

editors, Subhas K. Sikdar, Milan Bier, Paul Todd

CRC Press, c1990

Available at  / 4 libraries

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Note

Plenary lectures and poster presentations presented at the Frontiers in Bioprocessing Conference held June 28-July 2, 1987, Boulder, Colo

Includes bibliographies and index

Description and Table of Contents

Description

The goal of Frontiers in Bioprocessing is twofold. First, it provides an in-depth discussion of recent developments in bioprocessing. Second, it focuses on the critical assessment of the potential of newer processing and separation techniques, including the concepts of overall process integration. This book intends to stimulate interactions among participants from various disciplinary backgrounds. It includes such topics as fermentation research, process control and measurement technology, and separation and purification in downstream processing. Those who will find this publication particularly of interest are bioengineers, biotechnologists, microbiologists, chemical engineers, as well as those studying these fields.

Table of Contents

Problems and Challenges in the Production and Processing of Biologically Active Materials. PROCESS INTEGRATION. Development of a Reverse-Phase HPLC Process Step for Recombinant b-Interferon. Sensitivity Analysis of an Integrated Process of Lignocellulose Conversion to Ethanol. The Story of Biosynthetic Human Insulin. Purification and Sequencing of Interferons and Other Biologically Active Proteins and Polypeptides. ADVANCES IN FERMENTATION. Kinetics of Immobilized Cells: A Structured Model. Bioreactors and Models for Genetically Modified Organisms. Mammalian Cell Culture: An Overview of the Problems and Various Approaches for the Development of Large-Scale Systems. Use of Fungal Elicitors to Increase the Yield of Secondary Products in Plant Cell Cultures. Using a Structured Kinetic Model for Analyzing Instability in Recombinant Bacterial Cultures. Preliminary Analysis of a Hollow Fiber Extractive Fermentor for the Production of Ethanol. Simulation Results of Applying a Robust Multivariable Control Design Methodology to a Generalized Bacterial Growth System. RepA mRNA, a Potential Rate-Limiting Factor in Replication of R1 Plasmids. Bacillus subtilis as a Host of Recombinant Vectors: The Protease Problem. BIOSENSORS. Integrated Biosensors. Sensing Techniques for Bioprocess Monitoring and Control. Mass Fabricated Ion, Gas, and Enzyme Multispecies Sensors Using Integrated Circuit Technology. Flux Determination in Cellular Bioreaction Networks: Applications to Lysine Fermentations. BIOSEPARATIONS I: FREE FLUID METHODS. Analytical Cell Electrophoresis as a Tool in Preparative Cell Electrophoresis. Effective Principles for Scaleup of Electrophoresis. Electrophoresis Experiments in Space. Cell Partitioning in Two-Polymer-Phase Systems: Towards Higher Resolution Separations. Large-Scale Affinity Partitioning of Enzymes in Aqueous Two-Phase Systems. Computerized Strategy for Estimation of Protein Purity. BIOSEPARATIONS II: CHROMATOGRAPHIC METHODS. Purification of Proteins of Low Value in High Volume. High Performance Adsorption Separations. Preparative-Scale Chromatographic Processes: Ion-Exchange and Affinity Chromatographic Separations. Adsorption Chromatography: Approaches to Computer-Based Optimization and Modeling of Column Processes. Immobilized Metal Ion Affinity Chromatography of Transferrins. HPLC Scale Up for Uracil-DNA Glycosylase Purification. BIOSEP: A Novel Approach to Precompetitive Research in Downstream Processing. EMERGING TECHNOLOGIES IN BIOPROCESSING. Large-Scale Fluidized-Bed Bioreactor Systems. Multiphase Membrane Reactors for Enzymatic Resolution: Diffusional Effects on Stereoselectivity. Protein Engineering for the Development of Novel Affinity Separations. Microbial Metal Leaching and Resource Recovery Processes. Coal Biosolubilization.

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