Advances in drug research

著者

• Harper, N. J.
• Simmonds, Alma B.
• Testa, Bernard

書誌事項

Advances in drug research

Academic Press, 1964-

• v. 1
• v. 2
• v. 3
• v. 4
• v. 5
• v. 6
• v. 7
• v. 8
• v. 9
• v. 10
• v. 11
• v. 12
• v. 13
• v. 14
• v. 15
• v. 16
• v. 17
• v. 18
• v. 19
• v. 20
• v. 21
• v. 22
• v. 23
• v. 24
• v. 25
• v. 26
• v. 27
• v. 28
• v. 29
• v. 30

内容説明・目次

巻冊次

v. 13 ISBN 9780120133130

目次

Drugs? Drug Research? Advances in Drug Research? Musings of a Medicinal Chemist, B. Testa. The Binding of Drugs to Blood Plasma Macromolecules: Recent Advances and Therapeutic Significance, J.-P. Tillement, G. Houin, R. Zini, S. Urien, E. Albengres, J. Barre, M. Lecomte, P. D'Athis, and B. Sebille. Xenobiotic Metabolism by Brain Monooxygenases and Other Cerebral Enzymes, M. Mesnil, B. Testa, and P. Jenner. Central and Peripheral a-Adrenoceptors. Pharmacological Aspects and Clinical Potential, P.A. Van Zwieten and P.B.M.W.M. Timmermans. Novel Approaches to the Design of Safer Drugs: Soft Drugs and Site-Specific Chemical Delivery Systems, N. Bodor. Subject Index. Cumulative Index of Authors. Cumulative Index of Titles.

巻冊次

v. 15 ISBN 9780120133154

内容説明

The first three articles in the latest volume of this successful series consider topics of general interest: toxication mechanisms, the rational design of peptide drugs, and tissue and receptor selectivity. The final two reviews are dedicated to specific therapeutic classes of drugs, namely inhibitors of prostaglandin, thromboxane and leukotriene biosynthesis, and psychoactive amines of food origin.

目次

Toxication Mechanisms in Drug Metabolism. Elements for the Rational Design of Peptide Drugs. Tissue and Receptor Selectivity: Similarity and Differences. Inhibition of Prostaglandin, Thromboxane and Leukotriene Biosynthesis. Foodstuffs as sources of Psychoactive Amines and Their Precursors: Content, Significance and Identification. Chapter References. Index.

巻冊次

v. 16 ISBN 9780120133161

目次

Free Radicals in Drug Research, M.B. Roberfroid, H.G. Viehe, and J. Remacle. The Parametrization of Lipophilicity and other Structural Properties in Drug Design, H. Van De Waterbeemd and B. Testa. Structure-Activity Relationships and Mechanisms of Action of Antibacterial Sulphanilamides and Sulphones, P.G. De Benedetti. The Stereoelectronic Effects at the Opiate Receptor: their Influence on Affinity and Instrinsic Activity, V.M. Kolb. Drug Action and Cellular Calcium Regulation, R.A. Janis, P.J. Silver, and D.J. Triggle. Subject Index. Cumulative Index of Authors. Cumulative Index of Titles.

巻冊次

v. 18 ISBN 9780120133185

内容説明

Each volume in this distinguished series presents authoritative reviews, both generally, on topics of broad interest in drug research, and specifically, on novel and established therapeutic classes. Acknowledged experts contribute in areas such as drug design, clinical and molecular pharmacology, drug metabolism, and mechanisms of action. Reviewers have consistently praised Advances in Drug Research for its comprehensive and lucid summaries of up-to-date knowledge.

目次

B. Pullman, Molecular Mechanisms of Specificity in DNA-Antitumor Drug Interactions. W.L. Duax and J.F. Griffin, The Structure and Receptor Binding of Steroid Hormones. R. Sarges, Aldose Reductase Inhibitors: Structure-Activity Relationships and Therapeutic Potential. A.F. Casy, Opioid Receptors and Their Ligands: Recent Developments. T.W. Stone, Purine Receptors and their Pharmacological Roles. M. Sokolovsky, Muscarinic Cholinergic Receptors and their Interactions with Drugs. Index.

巻冊次

v. 19 ISBN 9780120133192

内容説明

Each volume in this distinguished series presents authoritative reviews on topics of broad interest in drug research and on novel and established therapeutic classes. Acknowledged experts contribute in areas such as drug design, clinical and molecular pharmacology, drug metabolism, and mechanisms of action. Reviewers have consistently praised Advances in Drug Research for its comprehensive and lucid summaries of up-to-date knowledge.

目次

B. Testa, Preface--"Not Known, Because Not Looked For." L.P. Balant, K. Roseboom, and U.M. Gundert-Remy, Pharmacokinetic Criteria for Drug Research and Development. H. Boxenbaum and R.W. D'Souza, Interspecies Pharmacokinetic Scaling, Biological Design and Neoteny. U.A. Meyer, U.M. Zanger, D. Grant, and M. Blum, Genetic Polymorphisms of Drug Metabolism. B.K. Keppler, M.R. Berger, Th. Klenner, and M.E. Heim, Metal Complexes as Antitumor Agents. R. Thomas, P. Gray, and J. Andrews, Digitalis: Its Mode of Action, Receptor, and Structure-Activity Relationships. Index.

巻冊次

v. 20 ISBN 9780120133208

内容説明

This volume contains information on the tissue bindings of drugs, pharmacognosy and histaminergic agonists and antagonists. The work is intended to be of use to pharmacologists, medicinal chemists and toxicologists.

目次

• Extrapolation of toxicologic and pharmacologic data from animals to humans, W.R.Chappell and J.Mordenti
• tissue binding versus plasma binding of drugs - general principles and pharmacokinetic consequences, B.Fitchl et al
• search for new drugs of plant origin, M.Hamburger et al
• histaminergic agonists and antagonists - recent developments, R.Leurs et al.

巻冊次

v. 21 ISBN 9780120133215

内容説明

Intended for pharmacologists, medicinal chemists and toxicologists, this text explains the current state of knowledge on drug targeting in the lymphatic system. It also provides coverage of developments in quinolone research and the design and therapeutic potential of peptides.

目次

• Drug targeting towards the lymphatics, S. Muranishi
• recent developments in the field of quinolone antibacterial agents, D.T.W. Chu and P.B. Fernandes
• design and therapeutic potential of peptides, A.S. Dutta.

巻冊次

v. 22 ISBN 9780120133222

内容説明

This volume in a series intersperses general themes (on, for example, the CSAR molecular modelling approach to drug design) with chapters on specific drug classes or targets (for example, the challenge of regulatory peptides).

目次

• Preface, testa
• atomic properties in QSAR models - development and value of an atom-centred index, L. B. Kier
• pharmacokinetics of peptides and protein - opportunities and challenges, C. McMartin
• towards genomic pharmacology - from membranal to nuclear receptors, P. Laduron and L.H. Hall
• medicinal chemistry of steroids - recent developments, F. J. Zeelan.

巻冊次

v. 23 ISBN 9780120133239

内容説明

Volume 23 of Advances in Drug Research continues the serial's new trend of shorter but more frequent volumes, and carries on the aim of interspersing chapters on general themes with those on specific topics. The opening chapter reviews the brain uptake of drugs, while subsequent chapters deal with the very topical and important areas of peptide drug design, and the development of inhibitors as potential drugs.

目次

K.L. Audus, P.J. Chikhale, D.W. Miller, S.E. Thompson, and R.T. Borchardt, Brain Uptake of Drugs: The Influence of Chemical and Biological Factors. M.S. Benedetti and P. Dostert, Monoamine Oxidase: From Physiology and Pathophysiology to the Design and Clinical Application of Reversible Inhibitors. J.L. Fauchere and C. Thurieau, Evaluation of the Stability of Peptides and Pseudopeptides as a Tool in Peptide Drug Design. G. Lawton, P.M. Paciorek, and J.F. Waterfall, The Design and Biological Profile of Angiotensin-Converting Enzyme Inhibitors.

巻冊次

v. 24 ISBN 9780120133246

内容説明

This text on advances in drug research includes chapters on structural evolution of retinoids and chronopharmacology in drug research and therapy.

目次

• Chronopharmacology in drug research and therapy, Pierre M. Belanger
• structural evolution of retinoids, Koichi Shudo and Hiroyuko Kagechika
• biochemical actions and clinical pharmacology of anti-imflammatory drugs, Kenneth M. Williams and Samual N. Breit
• drugs for filariasis - four decades of research, Satyavan Sharma.

巻冊次

v. 25 ISBN 9780120133253

内容説明

With Volume 25, the series has a new co-editor, Urs Meyer. While retaining the commitment to publish chapters on therapeutic or chemical classes and on general topics or concepts, the series' coverage will expand to include methodological chapters, and new areas of recognized or potential significance to drug research, especially in molecular pharmacology.

目次

W. Kalow and L. Bertilsson, Interethnic Factors Affecting Drug Response. M.H. Bickel, Factors Affecting the Storage of Drugs and Other Xenobiotics in Adipose Tissue. F.J. Zeelen, The Changing World of Steroids. S. Sharma, Design of New Drugs for Helminth Diseases: Lead Optimization n Benzimidazoles. K.L. Davis-Bruno and P.V. Halushka, Molecular Pharmacology and Therapeutic Potential of Thromboxane A2 Receptor Antagonists. A. Dolmella, G. Bandoli, and M. Nicolini, Alzheimers Disease: A Pharmacological Challenge. Subject Index.

巻冊次

v. 26 ISBN 9780120133260

内容説明

Volume 26 continues the trend of shorter, more frequent volumes. With Volume 25, the series gained a new co-editor, Urs Meyer. While retaining the commitment to publish chapters on therapeutic or chemical classes and on general topics or concepts, the series' coverage has expanded to include methodological chapters, and new areas of recognized or potential significance to drug research, especially in molecular pharmacology.

目次

L.B. Kier and B. Testa, Complexity and Emergence in Drug Research. M.S. Tute, Drug Design: the Present and the Future. K. Burki and B. Ledermann, Transgenic Animals as Pharmacological Tools. C.L. Crespi, Xenobiotic-metabolizing Human Cells as Tools for Pharmacological and Toxicological Research. J. Urquhart, Correlates of Variable Patient Compliance in Drug Trials: Relevance in the New Health Care Environment. Subject Index. Cumulative Index of Authors. Cumulative Index of Titles.

巻冊次

v. 27 ISBN 9780120133277

内容説明

Volume 27, the first thematic volume in the Series, provides an overview of present knowledge with regard to the pharmacological and clinical aspects of antidiabetic drugs. It aims to stimulate further consideration of possible concepts in the development of new antidiabetic drugs.

目次

Introduction. Regulation of Glucose Homeostasis. Clinical Aspects of Diabetes Mellitus. Mechanisms of Insulin Action. Therapeutic Use of Insulin. The Secretory Machinery of Insulin Release. Compounds Acting on Insulin Secretion: Sulphonylureas. Compounds Acting on Glucose Uptake: Biguanides. Compounds Acting on Glucose Absorption. Aldose Reductase Inhibitors as New Antidiabetic Drugs. Conclusions. References. Cumulative Index of Authors. Cumulative Index of Titles.

巻冊次

v. 28 ISBN 9780120133284

内容説明

This volume continues the trend for Advances in Drug Research of shorter, but more frequent volumes. In line with the tradition of the series, chapters on general themes are interspersed with chapters on specific drug classes and targets.

目次

M. Eichelbaum and A.S. Gross, Stereochemical Aspects of Drug, Action, and Disposition. C.-M. Andersson, A. Halberg, and T. Hogberg, Advances in the Development of Pharmaceutical Antioxidants. S.E. Kane, Multidrug Resistance of Cancer Cells. H. Schroder, Bioactivation of Organic Nitrates and Other Nitrovasodilators. R.A. Ettinger and H.F. DeLuca, The Vitamin D Endocrine System and its Therapeutic Potential. P.G. Strange, Dopamine Receptors: Studies on Their Structure and Function. Index.

巻冊次

v. 29 ISBN 9780120133291

内容説明

This volume continues the trend for Advances in Drug Research of shorter, but more frequent volumes. In line with the tradition of the series, chapters on general themes are interspersed with chapters on specific drug classes and targets.

目次

B. Testa and U.A. Meyer, Preface: The Search for Consensus. A. Giannis and F. Rubsam, Peptidomimetics in Drug Design. G.M.J. Beijersbergen van Henegouwen, Medicinal Photochemistry. S. Ray and I. Dwivedy, Development of Estrogen Antagonists as Pharmaceutical Agents. C.W. Jefford, Peroxidic Antimalarials.

巻冊次

v. 30 ISBN 9780120133307

内容説明

This volume continues the trend for Advances in Drug Research of shorter, but more frequent volumes. In line with the tradition of the series, chapters on general themes are interspersed with chapters on specific drug classes and targets. It will be the last volume edited by Bernard Testa and Urs A. Meyer.

目次

• The concept of emergence dissolvence in drug research, B. Testa and L.B. Kier
• sense and non-sense in toxicity assessment of medicinal products, A.G. Rauws, E.J. De Waal and J.W. van der Laan
• the concept of chiral conformers and its significance in molecular pharmacology, M. Simonyi
• combinational libraries for enhanced drug discovery, E.R. Felder and D. Poppinger
• reversal of chloroquine resistance in malaria - a new concept of chemotherapy, S. Batra and A.P. Bhaduri.

「Nielsen BookData」 より

詳細情報

• NII書誌ID(NCID): BA14099724
• ISBN:
  • 0120133016
  • 0120133024
  • 0120133032
  • 0120133059
  • 0120133067
  • 0120133075
  • 0120133083
  • 0120133091
  • 0120133105
  • 0120133113
  • 0120133121
  • 012013313X
  • 0120133148
  • 0120133156
  • 0120133164
  • 0120133172
  • 0120133180
  • 0120133199
  • 0120133202
  • 0120133210
  • 0120133229
  • 0120133237
  • 0120133245
  • 0120133253
  • 0120133261
  • 012013327X
  • 0120133288
  • 0120133296
  • 012013330X
• LCCN: 64024672
• 出版国コード: uk
• タイトル言語コード: eng
• 本文言語コード: eng
• 出版地: London ; Tokyo
• ページ数/冊数: v.
• 大きさ: 24 cm
• 分類:
  • NLM : W1
• 件名:
  • MESH : Drugs -- yearbooks
  • MESH : Pharmacology -- yearbooks