Tumor necrosis factors : the molecules and their emerging role in medicine

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書誌事項

Tumor necrosis factors : the molecules and their emerging role in medicine

editor, Bruce Beutler

Raven Press, c1992

大学図書館所蔵 件 / 全11件

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

This volume is a comprehensive review of the biology of tumour necrosis factor (TNF) lymphotoxin, two cytokines that cause a vast array of changes in cell behaviour in virtually every tissue and play a major role in a wide variety of disease processes, from endotoxic shock to bone resorption. More than 60 leading investigators in diverse basic science and clinical disciplines synthesize discoveries on the biosynthesis of these cytokines, their molecular structure, their signal transduction mechanisms in cells, their interactions with other cytokines, their effects on various tissues and organ systems, their tumor necrotizing activity, and their physiological and pathophysiological functions. The findings presented indicate that, while TNF can cause endotoxic shock, cachexia, inflammation, and bone resorption, it can also protect against the lethal outcome of various infections and attenuate the development of certain autoimmune diseases. The contributors also explore the potential medical uses of TNF and TNF inhibitors.

目次

  • Part 1 The structure of TNF: perspectives on biological activity, S.R. Sprang and M.J. Eck
  • the design and activities of TNF muteins, L.S. Lin. Part 2 The cell and tissue of TNF: modulation of endothelial cell hemostatic properties by TNF - insights into the role of endothelium in the host response to inflammatory stimuli, M. Clauss et al
  • TNF modulation of endothelial and neutrophil adhesion, J.R. Gamble et al
  • TNF and the liver, P. Ghezzi
  • the effects of TNF on eosinophils and eosinphilia-associated disease, D.S. Silberstein
  • effects of TNF on bone and cartilage, G.R. Mundy
  • TNF and hematopoiesis, G.D. Roodman. Part 3 Interactions with other cytokines: TNF and TGF-beta - the opposite sides of the avenue?, R.M. Flynn and M.A. Palladino
  • the synergy and antagonism of interferon and TNF, K.C.F Sheehan and R.D. Schreiber
  • interactions between TNF and GM-CSF, H.J. Ross and H.P. Koeffler
  • interactions between TNF and IL-1, D.C. Chaplin and K.A. Hogquist
  • effects of IL-2 and IL-4 on the synthesis of TNF - role of TNF in IL-2 toxicity, J.W. Mier et al. Part 4 Systemic effects of TNF: metabolic and nutritional effects of TNF, N.J. Rothwell and R.F. Grimble
  • the acute and chronic pathophysiology effects of TNF - mediation of septic shock and wasting (cachexia), K.J. Tracey. Part 5 The role of TNF in infectious and inflammatory diseases: detection and involvement of TNF in septic shock, A. Waage
  • TNF in listeriosis, A. Nakane
  • TNF in "legionella" infection, D.K. Blanchard
  • TNF in malaria, I.A. Clark et al
  • TNF and mycobacteria, G.E. Grau et al
  • TNF and alloreactions - involvement of TNF in the effector phase of graft-versus-host and host-versus-graft reactions, P.F. Piguet
  • the role of lymphotoxin and TNF in demyelinating diseases of the CNS, M. Broome Powell and L. Steinman
  • antiviral properties of TNF, G.H.W. Wong et al. Part 6 medical uses of TNF and TNF inhibitors: cancer chemotherapy - experiences with TNF administration in humans, D.R. Spriggs and S.W. Yates
  • the activity of TNF in experimental cancer models, S.T.A. Malik. Part 7 The mechanism of action of TNF: mechanism of cytotoxicity, cytolysis, and growth stimulation by TNF, C. Baglioni
  • TNF receptors and TNF signal transduction, K. Pfizenmaier et al
  • MnSOD induction by TNF and its protective role, G.H.W. Wong et al. Part 8 The regulation of TNF biosynthesis: the LPS gene - insights into the genetic and molecular basis of LPS responsiveness and macrophage differentiation, S.N. Vogel
  • lymphocytes and NK cells as producers of TNF, G. Trinchieri
  • TNF production by neutrophils - antifungal effects, J.Y. Djeu
  • the TNF and lymphotoxin promoters, C.V. Jongeneel
  • coordinate regulation of TNF biosynthesis at the levels of transcription and translation - patterns of TNF expression "in vivo", B. Beutler et al.

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