International Symposium on Pertussis: Evaluation and Research on Acellular Pertussis Vaccines

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書誌事項

International Symposium on Pertussis: Evaluation and Research on Acellular Pertussis Vaccines

proceedings of a symposium, supported by the National Institute of Health, Tokyo and the International Association of Biological Standardization held at the Teijin Institute of Education and Training, Shizuoka, Japan, September 14-15, 1990

（Developments in biological standardization, v. 73）

Karger, c1991

タイトル別名

Pertussis: Evaluation and Research on Acellular Pertussis Vaccines

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内容説明・目次

内容説明

Although systematic vaccination with whole cell pertussis vaccines has greatly contributed to controlling the disease, the reactions observed in children after vaccination have become an increasingly serious problem. The demand for a safer and more effective vaccine against whooping cough led to the development of a novel acellular vaccine in Japan in 1980 and subsequently to other types of non-reactive vaccine products. This publication reviews the results of the laboratory and clinical studies of acellular pertussis vaccines currently under trial. It also evaluates what needs to be done to resolve the uncertainties that still hamper the licensure of acellular vaccines outside Japan.

目次

  • Clinical studies on efficacy
  • molecular biology and genetics of B. pertussis
  • pertussis antigen and antibody
  • biological standardization for acellular pertussis vaccines - a general discussion
  • pertussis assay and detection systems
  • production and properties of pertussis vaccines
  • clinical trial on human response
  • epidemiology.

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