Myocardial protection : the pathophysiology of reperfusion and reperfusion injury

著者

書誌事項

Myocardial protection : the pathophysiology of reperfusion and reperfusion injury

editors, Derek M. Yellon, Robert B. Jennings

Raven Press, c1992

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注記

Based on a meeting held at Brocket Hall in the U.K., 1991, under the auspices of the Council on Cardiac Metabolism of the International Society and Federation of Cardiology

Includes bibliographical references and index

内容説明・目次

内容説明

This volume provides insight into current theories and controversies regarding myocardial reperfusion and reperfusion-induced injury. The concepts presented aim to advance the understanding of the direct relationship of reperfusion injury to the beneficial effects of restoring coronary flow to the myocardium after an ischemic insult. Additional chapters examine myocardial adaptive responses to ischemia, particularly the myocardial protective effects of ischemic preconditioning and stress protein synthesis. The book concludes with a discussion of current and future approaches to the problems associated with reperfusion injury.

目次

  • Reperfusion injury - definitions and historical background, Robert B. Jennings and Derek M. Yellon
  • myocardial injury during ischemia and reperfusion - concepts and controversies, David J. Hearse
  • do free radicals contribute to myocardial cell death during ischemia-reperfusion?, James M. Downey and Derek M. Yellon
  • the contribution of neutrophil activation and changes in endothelial function to myocardial ischemia-reperfusion injury, Kevin M. Mullane and Mark Young
  • consequences of ischemia-reperfusion on the coronary microvasculature, Robert A. Kloner and Karin Przykenk
  • postischemic myocardial "Stunning" - pathogenesis, pathophysiology and clinical relevance, Roberto Bolli
  • reperfusion injury - a clinical perspective, Keigh A.A. Fox
  • preconditioning - definitions, proposed mechanisms, and implications for myocardial protection in ischemia and reperfusion, Keith A. Reimer and Robert B. Jennings
  • stress proteins and myocardial protection during ischemia and reperfusion, Derek M. Yellon and David S. Latchman
  • where do we stand with respect to reperfusion in the 1990s? Clinical and experimental perspective, Lionel H. Opie.

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