Postimplantation development in the mouse
著者
書誌事項
Postimplantation development in the mouse
（Ciba Foundation symposium, 165）
Wiley, 1992
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注記
Editors, Derek J. Chadwick and Joan Marsh
"A Wiley-Interscience publication
Includes bibliographical references and indexes
内容説明・目次
内容説明
Postimplantation Development in the Mouse Chairman: A. McLaren 1992 This book contains an in-depth analysis of the state of knowledge of postimplantation development in the mouse. It concentrates on the mouse as an example of mammalian development, but refers to chick, amphibian and Drosophila embryogenesis where these organisms are more amenable to the study of particular problems. The establishment of the germ layers and other cell lineages in the early embryo is described, including details of cell movements during the early stages of primitive streak formation. Patterns of gene expression during the development of several tissues - for example, the central nervous system, the skeletal and muscle systems, and limb bud - are discussed with particular emphasis on commitment to specific cell types. There are chapters on the roles of genes in intercellular signalling and on the need for direct interactions between epithelia and mesenchymal cells in the formation of the kidney and tooth rudiment. These studies all use a combination of classical genetic approaches, cell biology and detailed molecular techniques.
Various methods for generating new mutations in known genes or at random are described and their comparative merits are evaluated. Finally, there are discussions of ways of amassing and disseminating the information that is becoming available on gene transcription in mouse embryogenesis, and also the mutated cell lines or mouse embryos themselves. Other Ciba Foundation Symposia: No. 144 Cellular basis of morphogenesis Chairman: L. Wolpert 1989 ISBN 0 471 92306 0 No. 150 Proto-oncogenes in cell development Chairman: T. Hunter 1990 ISBN 0 471 92686 8 No. 160 Regeneration of vertebrate sensory receptor cells Chairman: E. W. Rubel 1991 ISBN 0 471 92960 3
目次
Partial table of contents: Clonal Analysis of Cell Fate During Gastrulation and Early Neurulation in the Mouse (K. Lawson & R. Pedersen). Use of Chimeras to Study Gene Function in Mesodermal Tissues During Gastrulation and Early Organogenesis (R. Beddington, et al.). Action of the Brachyury Gene in Mouse Embryogenesis (B. Herrmann). Molecular Mechanisms of Pattern Formation in the Vetebrate Hindbrain (M. Nieto, et al.). Myogenesis in the Mouse (M. Buckingham, et al.). Development of the Skeletal System (R. Balling, et al.). Development of the Left--Right Axis (N. Brown, et al.). Use of Embryonic Stem Cells to Study Mutations Affecting Postimplantation Development in the Mouse (E. Robertson, et al.). Genetic Manipulation of the Mouse via Gene Targeting in Embryonic Stem Cells (A. Bradley, et al.). Indexes.
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