Design of anti-AIDS drugs
Author(s)
Bibliographic Information
Design of anti-AIDS drugs
（Pharmacochemistry library, v. 14）
Elsevier , Distributors for the U.S. and Canada, Elsevier Science Pub. Co, 1990
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Includes bibliographical references and index
Description and Table of Contents
Description
There are several steps in the replicative cycle of human immunodeficiency virus (HIV) that could be considered as adequate targets for chemotherapeutic intervention, e.g., virus attachment to the cells, virus penetration and uncoating, transcription of the viral (RNA) genome to proviral DNA, integration of the proviral DNA into host cell DNA, transcription of the proviral precursor proteins to mature viral proteins, assembly and release ('budding') of the viral particles. These processes depend on, and are regulated by, specific viral proteins. This makes many of these processes and proteins plausible targets for the design of selective inhibitors. The contributions assembled in this book are aimed at presenting what is known anno 1990 about (1) the different steps in the HIV replicative cycle that could be considered as targets for anti-HIV agents, (2) the compounds that interact with these targets and offer promise as candidate drugs for the treatment of HIV infection, and (3) to the extent that it has been resolved, the mechanism of interaction of the anti-HIV agents with their putative targets.
Table of Contents
Perspectives for the chemotherapy of HIV infection: An introduction (E. De Clerq). Toward targeted therapy for HIV infection (H. Mitsuya, T. Shirasaka and S. Broder). HIV-CD4 interaction as target for anti-HIV agents (D. Schols and E. De Clerq). Sulfated polymers as inhibitors of HIV replication (M. Baba and E. De Clercq). Potent and selective inhibition of HIV-1 replication in vitro by a novel series of tetrahydro-imidazo [4,5,1-jk][1,4]-benzodiazepin-2(1H)-one and -thione (TIBO) derivatives (R. Pauwels, K. Andries, J. Desmyter, M.J. Kukla, J. Hyekants, E. De Clercq and P.A.J. Janssen). HIV reverse transcriptase as a target for antiviral drugs (K.L. Powell and G. Darby). Dideoxynucleoside analogues as inhibitors of HIV replication (P. Herdewijn and E. De Clercq). Acyclic and carbocyclic nucleoside analogues as inhibitors of HIV replication (J. Balzarini and E. De Clercq). Antisense oligonucleotides as an approach towards anti-AIDS therapy (J.S. Cohen). HIV-1 protease as a target for potential anti-AIDS drugs (T.D. Meek, D.M. Lambert, B.W. Metcalf, S.R. Petteway, Jr. and G.B. Dreyer). Glycoprotein synthesis and human immunodeficiency viruses: A target for chemotherapy (A.S. Tyms, D.L. Taylor, P.S. Sunkara and M.S. Kang). Animal models for anti-AIDS therapy (R.M. Ruprecht). The clinical use of anti-HIV agents (D.D. Richman). Subject index.
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