In vitro toxicity testing : applications to safety evaluation

著者

    • Frazier, John M.

書誌事項

In vitro toxicity testing : applications to safety evaluation

edited by John M. Frazier

Marcel Dekker, c1992

大学図書館所蔵 件 / 全5件

この図書・雑誌をさがす

注記

Includes bibliographical references and index

内容説明・目次

内容説明

This volume focuses on the potential application of in vitro procedures to identify and quantify the toxicological risk to target organs associated with the use of commerical products and therapeutic drugs.;Revealing how the results of in vitro toxicity testing can be used in safety assessment, In Vitro Toxicity Testing: explores whether existing test methods can accomplish the necessary goals and, if not, what research is needed to make these techniques a practical reality; presents the current status of toxicity testing in the areas of hepatotoxicity, renal toxicity, ocular irritation, and many others; outlines the role of validation in technology transfer from the research laboratory to safety evaluation; examines testing strategies and regulatory acceptance and addresses common concerns about the ultimate utilization of available methods in chemical safety/hazard considerations; and analyzes the perspective of industrial and regulatory agencies on the application of in vitro toxicity testing.;Generously referenced with over 1400 literature citations, In Vitro Toxicity Testing is for academic, industrial, and regulatory toxicologists; applied, molecular, and cell biologists; pharmacologists; animal welfare activists; and graduate students in pharmacology and toxicology courses.

目次

  • General perspectives on in vitro toxicity testing, John M. Frazier
  • in vitro technology, trends and issues, Charles A. Tyson and Neill H. Stacey
  • hepatotoxicity, Andre Guillouzo
  • an evaluation of in vitro models for assessing nephrotoxicity, Patricia D. Williams and Glenn F. Rush
  • neurotoxicity, Alan L. Harvey
  • cardiovascular toxicity, Kenneth Ramos and Daniel Acosta
  • ocular irritation, Leon H. Bruner
  • cutaneous irritancy, Vincent A. DeLeo
  • in vitro teratogenicity, Barbara F. Hales
  • carcinogenicity - the use of animal models and short-term predictive tests, David J. Brusick
  • validation of in vitro toxicity tests, John M. Frazier
  • industrial applications for in vitro toxicity evaluation - a tier testing strategy for product safety assessment, Shayne Cox Gad
  • regulatory law and the use of in vitro methods for the assessment of various toxicities, Sidney Green and June A. Bradlaw.

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