Cerebral pathophysiology : an integral approach with some emphasis on clinical implications

著者

書誌事項

Cerebral pathophysiology : an integral approach with some emphasis on clinical implications

K.G. Go

Elsevier , Sole distributors for the USA and Canada, Elsevier Science Pub. Co., 1991

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注記

Includes bibliographical references (p. 332-407) and index

内容説明・目次

内容説明

Neuronal function, underlying integrative activities of the brain, has long appealed to investigators of the nervous system. The pathophysiological responses of the central nervous system to injuries is of importance to the integrity and survival of the neural tissue. However, the role of neurons in these responses consists more of their participation in tissue metabolism rather than of their functional involvement. This volume on cerebral pathophysiology provides an excellent overview of the phenomena which manifest themselves in the actue consequences of insults to the central nervous system. Specific sections focus on blood-brain barrier, alteration of fluid balance and electrolyte contents, perturbation of cell volume and pH homeostasis, interference with the reactivity of the vascular system, and their repercussions with respect to the craniospinal pressure/volume relations and the eventual compromise of tissue energy metabolism. The vaste accumulation of research in this area has been very specialized and thus fragmented especially when transcending disciplines. This volume assimilates these different subjects into a mutual perspective that covers these various fields.

目次

I. THE BLOOD-BRAIN AND BLOOD-CEREBROSPINAL FLUID BARRIERS 1. Phenomenological aspects 2. Morphological aspects of the blood-brain barrier 3. Cytochemicial aspects of the blood-brain barrier. II. THE FLUID ENVIRONMENT OF THE CENTRAL NERVOUS SYSTEM 1. Brain water 2. The extracellular space 3. Brain tissue electrolytes 4. The cerebrospinal fluid 5. Disturbances of fluid balance. III. INTRACRANIAL PRESSURE 1. Methods for the measurement of intracranial pressure. IV. THE CEREBRAL BLOOD SUPPLY 1. The supply of substrate 2. The Supply of Oxygen 3. Vascular anatomy 4. Technical principles in measurement of cerebral blood flow 5. Cerebral blood volume 6. Characteristics of microcirculation 7. Responses of the cerebrovascular system 8. Mediators of vasomotor responses 9. Cerebral vasospasm in subarachnoid hemorrhage 10. Molecular mechanisms of vascular tone and its control 11. Disturbances of vascular blood supply. V. ENERGY METABOLISM OF THE BRAIN 1. The purpose of substrate oxidation 2. Pathways of energy metabolism 3. Parameters of energy metabolism 4. Perturbations of cerebral energy metabolism. References. Index.

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