Molecular aspects of inflammation
著者
書誌事項
Molecular aspects of inflammation
Springer-Verlag, 1991
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
Understanding the molecular basis of complex biological processes has been a major goal in biological chemistry for some time. Inflammation is such a process, and recent years have seen exciting progress in the understanding of molecular interactions; there has been a long way from dolor, rubor, calor and tumor as a fundamental desciption of the phenomenon to current knowledge on e.g. the control of the respiratory burst of the granulocyte, the atomic details of protease regulation, or the interaction of cytokines. The book is organized in order of increasing complexity, starting out with the key phenomena of the inflammatory response and its modulation by cytokines to introvascular events and shock and sepsis; thus, the current attempts to apply basic knowledge on mediators of inflammation to the clinical situation are also considered.
目次
Basic Mechanisms of the Inflammatory Response.- Neutrophils, Interleukin 8, and Related Chemotactic Cytokines.- Leukotrienes and Chemotaxis-5-Lipoxygenase Activation and Control.- The Respiratory Burst Oxidase.- Cellular Activation Mechanisms: The Blood Platelet as a Model.- Platelet-Neutrophil Interactions.- Proteolysis-Induced Pathomeehanisms in Acute Inflammation and Related Therapeutic Approaches.- Complement Activation.- Proteinase-Protein Inhibitor Interaction.- Attenuation of Inflammatory Disease by Reduction of Interleukin-1 Production or Receptor Antagonism.- Interleukin-6, Its Hepatic Receptor and the Acute Phase Response of the Liver.- Transcriptional Control of Liver Acute Phase Genes by Interleukin-6 and Leukemia Inhibitory Factor.- Disturbance of the Hemostasis and Fibrinolysis Balance by Tumor Necrosis Factor.- Cellular Injury by Oxidants.- Endothelium-Derived Relaxing Factor: Nitric Oxide.- Molecular Aspects of the Chemistry and Biology of Endotoxin.- Bacterial Exotoxins and Acute Lung Failure.- Pathophysiological Aspects of Polytrauma, Shock, and Organ Failure.- Leukotrienes, Oxygen Radicals, and Cytokines in Septicemic Mice.- Baboon Model of E. Coli Sepsis: Summary of Staging, Mechanism, and Diagnostic Markers.
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