Ion channels

著者

• Rudy, Bernardo
• Iverson, Linda E.
• Conn, P. Michael

書誌事項

Ion channels

edited by Bernardo Rudy, Linda E. Iverson

（Methods in enzymology / editors in chief, Sidney P. Colowick, Nathan O. Kaplan, v. 207, 293-294）

Academic Press, c1992-c1999

• [pt. A]
• [pt. A] : comb
• pt. B
• pt. C

注記

Includes bibliographical references and indexes

pt. B, C: edited by P. Michael Conn

内容説明・目次

巻冊次

[pt. A] ISBN 9780121821081

内容説明

This book describes modern electrophysiological techniques for recording and analysis of ion channels in various systems including cells in culture, Xenopus oocytes, brain slices, cellular organelles, and microorganisms. Many chapters deal with the prevention and correction of electrophysiological artifacts. Also included are methods for the purification and expression of ion channel genes and proteins.

目次

• Contributors. Preface. Volumes in Series. Section I: Modern Applications of Electrophysiological Techniques: Patch Clamp Techniques: An Overview, M. Cahalan and E. Neher. Constructing a Patch Clamp Setup, R.A. Levis and J.L. Rae. Glass Technology for Patch Clamp Electrodes, J.L. Rae and R.A. Levis. Ion Channel Selectivity, Permeation, and Block, T. Begenisich. Access Resistance and Space Clamp Problems Associated with Whole-Cell Patch Clamping, C.M. Armstrong and W.F. Gilly. Correction for Liquid Junction Potentials in Patch Clamp Experiments, E. Neher. Nonstationary Noise Analysis and Application to Patch Clamp Recordings, S.H. Heinemann and F. Conti. Prevention of Rundown in Electrophysiological Recording, R. Horn and S.J. Korn. Patch Voltage Clamping with Low-Resistance Seals: Loose Patch Clamp, W.M. Roberts and W. Almers. Perfusing Patch Pipettes, J.M. Tang, J. Wang, and R.S. Eisenberg. Whole-Cell Recording of Calcium Channel Currents, B.P. Bean. Recording from Calcium-Activated Potassium Channels, B.S. Pallotta, A.L. Blatz and K.L. Magleby. Patch-Clamping Cells in Sliced Tissue Preparations, F.A. Edwards and A. Konnerth. Section II. Expression of Ion Channels: A.: Expression of Ion Channels in Xenopus Oocytes: Xenopus Oocyte Microinjection: From Gene to Protein, H. Soreq and S. Seidman. Maintenance of Xenopus laevis and Oocyte Injection, A.L. Goldin. Preparation of RNA for Injection into Xenopus Oocytes, A.L. Goldin and K. Sumikawa. Tissue RNA as Source of Ion Channels and Receptors, T.P. Snutch and G. Mandel. In Vitro Synthesis of RNA for Expression of Ion Channels in Xenopus Oocytes, T. Snutch and G. Mandel. Electrophysiological Recording from Xenopus Oocytes, W. Stuhmer. Use of Stage II-III Xenopus Oocytes to Study Voltage-Dependent Ion Channels, D.S. Krafte and H.A. Lester. Intracellular Perfusion of Xenopus Oocytes, N. Dascal, G. Chilcott, and H.A. Lester. Recording of Gating Currents from Xenopus Oocytes and Gating Noise Analysis, S.H. Heinemann, F. Conti, and W. Stuhmer. Ligand-Binding Assays in Xenopus Oocytes, A.L. Buller and M.M. White. Expression of Gap Junctional Proteins in Xenopus Oocyte Pairs, L. Ebihara. Regulation of Intracellular Calcium Activity in Xenopus Oocytes, Y. Oron and N. Dascal. B. Expression of Ion Channels Using Other Systems: Stable Expression of Heterologous Multisubunit Protein Complexes Established by Calcium Phosphate- or Lipid-Mediated Cotransfection, T. Claudio. Vaccinia Virus as Vector to Express Ion Channel Genes, A. Karschin, B.A. Thorne, G. Thomas, and H.A. Lester. Expression of Ion Channels in Cultured Cells Using Baculovirus, A. Kamb, J.I. Korenbrot, and J. Kitajewski. Probing Molecular Structure and Structural Changes of Voltage-Gated Channel by Expressing Mutant Channels in Yeast and Reconstituting Them into Planar Membranes, M. Colombini, S. Peng, E. Blachly-Dyson, and M. Forte. Section III. Reconstitution of Ion Channels in Lipid Bilayers: Insertion of Ion Channels into Planar Lipid Bilayers by Vesicle Fusion, P. Labarca and R. Latorre. Planar Lipid Bilayers on Patch Pipettes: Bilayer Formation and Ion Channel Incorporation, B.E. Ehrlich. Surface Charge Effects on Ion Conduction in Ion Channels, R. Latorre, P. Labarca, and D. Naranjo. Determination of Ion Permeability by Fluorescence Quenching, A.M. Garcia. Synthetic Peptides and Proteins as Models for Pore-Forming Structure of Channel Proteins, A. Grove, T. Iwamoto, M.S. Montal, J.M. Tomich, and M. Montal. Section IV. Purification of Ion Channel Proteins and Genes: Purification and Reconstitution of Skeletal Muscle Calcium Channels, V. Florio, J. Striessnig, and W.A. Catterall. Purification and Reconstitution of Nicotinic Acetylcholine Receptor, A. Chak and A. Karlin. Purification, Affinity Labeling, and Reconstitution of a Voltage-Sensitive Potassium Channels, H. Rehm and M. Lazudunski. Affinity Purification and Reconstitution of Calcium-Activated Potassium Channels, D.A. Klaerke and P.L. J#248
• rgensen. Assay and Purification of Neuronal Receptors for Inositol 1,4,5-Triphosphate, S.R. Hingorani and W.S. Agnew. Isolation of Ion Channel Genes by Expression Cloning in Xenopus Oocytes, G.C. Frech and R.H. Joho. Hybrid Arrest Technique to Test for Functional Roles of Cloned cDNAs and to Identify Homologies among Ion Channel Genes, I. Lotan. Cloning of Ion Channel Gene Families Using the Polymerase Chain Reaction, E. Vega-Saenz De Miera and J.-W. Lin. Overview of Toxins and Drugs as Tools to Study Excitable Membrane Ion Channels I: Voltage-Activated Channels, T. Narahashi and M.D. Herman. Overview of Toxins and Drugs as Tools to Study Excitable Membrane Ion Channels II: Transmitter-Activated Channels, T. Narahashi. Biosynthesis of Ion Channels in Cell-Free and Metabolically Labeled Cell Systems, W.B. Thornhill and S.R. Levinson. Section V. Recording of Ion Channels of Cellular Organelles and Microorganisms: Patch Clamp Techniques in Study of Ion Channels from Organelles, B.U. Keller and R. Hedrich. Patch Clamp Studies of Microbial Ion Channels, Y. Saimi, B. Martinac, A.H. Delcour, P.V. Minorsky, M.C. Gustin, M.R. Culbertson, J. Adler, and C. Kung. Studies on Intact Sarcoplasmic Reticulum: Patch Clamp Recording and Tension Measurement in Lobster Split Muscle Fibers, J.M. Tang, J. Wang, and R.S. Eisenberg. Planar Bilayer Recording of Ryanodine Receptors of Sarcoplasmic Reticulum, R. Coronado, S. Kawano, C.J. Lee, C. Valdivia, and H.H. Valdivia. Section VI. Data Storage and Analysis: Software for Acquisition and Analysis of Ion Channel Data: Choices, Tasks, and Strategies, R.J. French and W.F. Wonderlin. Stationary Single-Channel Analysis, M.B. Jackson. Analysis of Nonstationary Single-Channel Currents, F.J. Sigworth and J. Zhou. Preventing Artifacts and Reducing Errors in Single-Channel Analysis, K.L. Magleby. Analysis of Drug Action at Single-Channel Level, E. Moczydlowski. Analysis of Sodium Channel Tail Currents, G. Cota and C.M. Armstrong. Calculation of Ion Currents from Energy Profiles and Energy Profiles from Ion Currents in a Multibarrier, Multisite, Multioccupancy Channel Model, O. Alvarez, A. Villarroel, and G. Eisenman. Author Index. Subject Index.

巻冊次

pt. B ISBN 9780121821944

内容説明

This volume plus its companion, Volume 294, presents cutting edge techniques for the study of ion channels, ranging from the molecular to the physiological level. These volumes supplement Volume 207 of Methods inEnzymology

目次

Assembly: J. Xu and M. Li, Methods Used to Study Subunit Assembly of Potassium Channels. Z.F. Sheng and C. Deutsch, Assembly of Ion Channels. J.S. Trimmer, Analysis of K+ Channel Biosynthesis and Assembly in Transfected Mammalian Cells. Genetics: T.M. Ishii, P. Zerr, X-m. Xia, C.T. Bond, J. Maylie, and J.P. Adelman, Site-Directed Mutagenesis. S. Richard, P. Lory, E. Bourinet, and J. Nargeot, Molecular Physiology of Human Cardiovascular Ion Channels: From Electrophysiology to Molecular Genetics. R.L. Nakamura and R.F. Gaber, Studying Ion Channels Using Yeast Genetics. M. Tiethammer and M. Sheng, Identification of Ion Channel-Associated Proteins Using Yeast Two-Hybrid System. A. Karlin and M.H. Akabas, Substituted-Cysteine Accessibility Method. R. Horn, Explorations of Voltage-Dependent Conformational Changes Using Cysteine Scanning. K. Sato and M. Tohyama, Assessment of Distribution of Cloned Ion Channels in Neuronal Tissues. Electrophysiology: J.W. Hanrahan, Z. Kone, C.J. Mathews, J. Luo, Y. Jia, and P. Linsdell, Patch Clamp Studies of Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel. T.J. Nelson, P.A. Gusev, and D.L. Alkon, Identification of Ion Channel Regulating Proteins by Patch Clamp Analysis. S.R. Lockery and M.B. Goodman, Tight-Seal Whole-Cell Patch Clamping of Caenorhabditis elegans Neurons. R.A. Levis and J.L. Rae, Low Noise Patch Clamp Techniques. D.N. Hilgemann and C.C. Lu, Giant Membrane Patches: Improvements and Applications. W. Stuhmer, Electrophysiological Recordings from Xenopus Oocytes. E. Stefani and F. Bezanilla, Cut-Open Oocyte Voltage Clamp Technique. S. Kaneko, A. Akaike, and M. Satoh, Cut-Open Recording Techniques. F. Bezanilla and E. Stefani, Gating Currents. J.G. Borst and F. Helmchen, Calcium Influx During Action Potentials. L.D. Partridge, H.U. Zeilhofer, and D. Swandulla, Combined Whole-Cell and Single-Channel Current Measurement with Quantitative Ca2+ Injection or Fura-2 Measurement of Ca2+. T. Begenisich, Determining Ion Channel Permeation Properties. R. Steffan, C. Hennesthal, and S.H. Heinemann, Voltage-Dependent Ion Channels: Analysis of Nonideal Macroscopic Current Data. S.H. Chung and P.W. Gage, Signal Processing Techniques for Channel Current Analysis Based on Hidden Markov Models. B.S. Rothberg and K.L. Magleby, Investigating Single-Channel Gating Mechanisms through Analysis of Two-Dimensional Dwell-Time Distributions. Expression Systems: K. Radford and G. Buell, Expression of Ligand-Gated Ion Channels Using Semliki Forest Virus and Baculovirus. M.U. Ehrengruber, M. Lanzrein, Y. Xu, M.C. Jasek, D.B. Kantor, E.M. Schuman, H.A. Lester, and N. Davidson, Recombinant Adenovirus-Mediated Expression in Nervous System of Genes Coding for Ion Channels and Other Molecules Involved in Synaptic Function. M.W. Nowak, J.P. Gallivan, S.K. Silverman, C.G. Labarca, D.A. Dougherty, and H.A. Lester, In Vivo Incorporation of Unnatural Amino Acids into Ion Channels in Xenopus Oocyte Expression System. T.M. Shih, R.D. Smith, L. Toro, and A.L. Goldin, High-Level Expression and Detection of Ion Channels in Xenopus Oocytes. P. Stampe and T. Begenisich, Unidirectional Fluxes through Ion Channels Expressed in Xenopus Oocytes. A.L. Eertmoed, Y.F. Vallejo, and W.N. Green, Transient Expression of Heteromeric Ion Channels. Model Simulations: M.J. Sutcliffe, A.H. Smeeton, Z.G. Wo, and R.E. Oswald, Molecular Modeling of Ligand-Gated Ion Channels. S.P. Scott and J.C. Tanaka, Use of Homology Modeling to Predict Residues Involved in Ligand Recognition. M.S.P. Sansom, Ion Channels: Molecular Modeling and Simulation Studies. M.E. Green, Computer Simulation and Modeling of Ion Channels. V. Ardonin and T. Hoshi, Kinetic Models and Simulation: Practical Approaches and Implementation Notes. Subject Index. Author Index.

巻冊次

pt. C ISBN 9780121821951

内容説明

General Description of the Volume:This volume and its companion Volume 293 present techniques for the study of ion channels, ranging from the molecular to the physiological level. These volumes supplement Volume 207 of Methods in Enzymology. General Description of the Series:The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.

目次

Contributors to Volume 294.Preface.Volumes in Series.Physical Methods:Optical Measurements of Calcium Signals in Mammalian Presynaptic Terminals, P. Saggau, R. Gray and J.A. Dani.Fluorescent Techniques for Measuring Ion Channel Activity, G. Velicelebi, K.A. Strauderman, M.A. Varney, M. Akong, S.D. Hess and E.C. Johnson.Tagging Potassium Ion Channels with Green Fluorescent Protein to Study Mobility and Interactions with Other Proteins, E.S. Levitan.Spin Label Electron Spin Resonance and Fourier Transform Spectroscopy for Structural/Dynamic Measurements on Ion Channels, D. Marsh.Nuclear Magnetic Resonance Spectroscopy of Peptide Ion Channel Ligands: Cloning and Expression as Aid to Evaluation of Structural and Dynamic Properties, M.D. Reily, A.M. Bokman, J. Offord and P. McConnell.Ligand Binding Methods for Analysis of Ion Channel Structure and Function, S.E. Pedersen, M.M. Lurtz and R.V.L. Papineni.Three-Dimensional Structure of Membrane Proteins Determined by Two-Dimensional Crystallization, Electron Cryomicroscopy, and Image Analysis, M. Yeager, V.M. Unger and A.K. Mitra.Drug-Dependent Ion Channel Gating by Application of Concentration Jumps Using U-Tube Technique, F. Bretschneider and F. Markwardt.Voltage Clamp Biosensors for Capillary Electrophoresis, O. Orwar, K. Jardemark, C. Farre, I. Jacobson, A. Moscho, J.B. Shear, H.A. Fishman, S.J. Lillard and R.N. Zare.Ion Channels as Tools to Monitor Lipid Bilayer-Membrane Protein Interactions: Gramicidin Channels as Molecular Force Transducers, O.S. Andersen, C. Nielsen, A.M. Maer, J.A. Lundbaek, M. Goulian and R.E. Koeppe, III.Purification and Reconstitution:Purification and Reconstitution of Epithelial Chloride Channel Cystic Fibrosis Transmembrane Conductance Regulator, M. Ramjeesingh, E. Garami, L.-J. Huan, K. Galley, C. Li, Y. Wang and C.E. Bear.Purification, Characterization, and Reconstitution of Cyclic Nucleotide-Gated Channels, R.S. Molday and L.L. Molday.Purification and Heterologous Expression of Inhibitory Glycine Receptors, B. Laube and H. Betz.Purification and Functional Reconstitution of High-Conductance Calcium-Activated Potassium Channel from Smooth Muscle, M.L. Garcia, K.M. Giangiacomo, M. Hanner, H.-G. Knaus, O.B. McManus, W.A. Schmalhofer and G.J. Kaczorowski.Reconstitution of Native and Cloned Channels into Planar Bilayers, I. Favre, Y.-M. Sun and E. Moczydlowski.Iodide Channel of the Thyroid: Reconstituting Ion Channels into Planar Lipid Bilayers, P.E. Golstein, A. Sener, F. Colin and R. Beauwens.Nystatin/Ergosterol Method for Reconstituting Ion Channels into Planar Lipid Bilayers, D.J. Woodbury.Isolation of Transport Vesicles That Deliver Ion Channels to the Cell Surface, S. Sattsangi and W.F. Wonderlin.Second Messengers and Biochemical Approaches:Protein Phosphorylation of Ligand-Gated Ion Channels, A.L. Mammen, S. Kamboj and R.L. Huganir.Analysis of Ion Channel Associated Proteins, M. Wyszynski and M. Sheng.Signal Transduction through Ion Channels Associated with Excitatory Amino Acid Receptors, K. Ogita and Y. Yoneda.Secondary Messenger Regulation of Ion Channels/Plant Patch Clamping, S.M. Assmann and L. Romano.Special Channels:ATP-Sensitive Potassium Channels, M. Schwanstecher, C. Schwanstecher, F. Chudziak, U. Panten, J.P. Clement IV, G. Gonzalez, L. Aguilar-Bryan and J. Bryan.Mechanosensitive Channels of Bacteria, P. Blount, S.I. Sukharev, P.C. Moe, B. Martinac and C. Kung.Simplified Fast Pressure-Clamp Technique for Studying Mechanically Gated Channels, D.W. McBride, Jr. and O.P. Hamill.Virus Ion Channels, D.C. Ogden, I.V. Chizhmakov, F.M. Geraghty and A.J. Hay.Ion Channels in Microbes, Y. Saimi, S.H. Loukin, X.-L. Zhou, B. Martinac and C. Kung.Design and Characterization of Gramicidin Channels, D.V. Greathouse, R.E. Koeppe II, L.L. Providence, S. Shobana and O.S. Andersen.Functional Analyses of Aquaporin Water Channel Proteins, P. Agre, J.C. Mathai, B.L. Smith and G.M. Preston.Toxins and Other Membrane Active Compounds:Pore-Blocking Toxins as Probes of Voltage-Dependent Channels, R.J. French and S.C. Dudley, Jr..Conus Peptides as probes for Ion Channels, J.M. McIntosh, B.M. Olivera and L.J. Cruz.Scorpion Toxins as Tools for Studying Potassium Channels, M.L. Garcia, M. Hanner, H.-G. Knaus, R. Slaughter and G.J. Kaczorowski.Potassium Ion Channel Inactivation Peptides, R.D. Murrell-Lagnado.Interactions of Snake Dendrotoxins with Potassium Channels, W.F. Hopkins, M. Allen and B.L. Tempel.Use of Planar Lipid Bilayer Membranes for Rapid Screening of Membrane Active Compounds, T.A. Mirzabekov, A.Y. Silberstein and B.L. Kagan.Reagent and Information Sources:Antibodies to Ion Channels, A.C. Vincent, I.K. Hart, A. Pinto and F.A. Stephenson.Internet Information on Ion Channels: Issues of Access and Organization, E.C. Conley.Author Index.Subject Index.

巻冊次

[pt. A] : comb ISBN 9780126016956

内容説明

This book describes modern electrophysiological techniques for recording and analysis of ion channels in various systems including cells in culture, Xenopus oocytes, brain slices, cellular organelles, and microorganisms. Many chapters deal with the prevention and correction of electrophysiological artifacts. Also included are methods for the purification and expression of ion channel genes and proteins.

目次

• Contributors. Preface. Volumes in Series. Section I: Modern Applications of Electrophysiological Techniques: Patch Clamp Techniques: An Overview, M. Cahalan and E. Neher. Constructing a Patch Clamp Setup, R.A. Levis and J.L. Rae. Glass Technology for Patch Clamp Electrodes, J.L. Rae and R.A. Levis. Ion Channel Selectivity, Permeation, and Block, T. Begenisich. Access Resistance and Space Clamp Problems Associated with Whole-Cell Patch Clamping, C.M. Armstrong and W.F. Gilly. Correction for Liquid Junction Potentials in Patch Clamp Experiments, E. Neher. Nonstationary Noise Analysis and Application to Patch Clamp Recordings, S.H. Heinemann and F. Conti. Prevention of Rundown in Electrophysiological Recording, R. Horn and S.J. Korn. Patch Voltage Clamping with Low-Resistance Seals: Loose Patch Clamp, W.M. Roberts and W. Almers. Perfusing Patch Pipettes, J.M. Tang, J. Wang, and R.S. Eisenberg. Whole-Cell Recording of Calcium Channel Currents, B.P. Bean. Recording from Calcium-Activated Potassium Channels, B.S. Pallotta, A.L. Blatz and K.L. Magleby. Patch-Clamping Cells in Sliced Tissue Preparations, F.A. Edwards and A. Konnerth. Section II. Expression of Ion Channels: A.: Expression of Ion Channels in Xenopus Oocytes: Xenopus Oocyte Microinjection: From Gene to Protein, H. Soreq and S. Seidman. Maintenance of Xenopus laevis and Oocyte Injection, A.L. Goldin. Preparation of RNA for Injection into Xenopus Oocytes, A.L. Goldin and K. Sumikawa. Tissue RNA as Source of Ion Channels and Receptors, T.P. Snutch and G. Mandel. In Vitro Synthesis of RNA for Expression of Ion Channels in Xenopus Oocytes, T. Snutch and G. Mandel. Electrophysiological Recording from Xenopus Oocytes, W. Stuhmer. Use of Stage II-III Xenopus Oocytes to Study Voltage-Dependent Ion Channels, D.S. Krafte and H.A. Lester. Intracellular Perfusion of Xenopus Oocytes, N. Dascal, G. Chilcott, and H.A. Lester. Recording of Gating Currents from Xenopus Oocytes and Gating Noise Analysis, S.H. Heinemann, F. Conti, and W. Stuhmer. Ligand-Binding Assays in Xenopus Oocytes, A.L. Buller and M.M. White. Expression of Gap Junctional Proteins in Xenopus Oocyte Pairs, L. Ebihara. Regulation of Intracellular Calcium Activity in Xenopus Oocytes, Y. Oron and N. Dascal. B. Expression of Ion Channels Using Other Systems: Stable Expression of Heterologous Multisubunit Protein Complexes Established by Calcium Phosphate- or Lipid-Mediated Cotransfection, T. Claudio. Vaccinia Virus as Vector to Express Ion Channel Genes, A. Karschin, B.A. Thorne, G. Thomas, and H.A. Lester. Expression of Ion Channels in Cultured Cells Using Baculovirus, A. Kamb, J.I. Korenbrot, and J. Kitajewski. Probing Molecular Structure and Structural Changes of Voltage-Gated Channel by Expressing Mutant Channels in Yeast and Reconstituting Them into Planar Membranes, M. Colombini, S. Peng, E. Blachly-Dyson, and M. Forte. Section III. Reconstitution of Ion Channels in Lipid Bilayers: Insertion of Ion Channels into Planar Lipid Bilayers by Vesicle Fusion, P. Labarca and R. Latorre. Planar Lipid Bilayers on Patch Pipettes: Bilayer Formation and Ion Channel Incorporation, B.E. Ehrlich. Surface Charge Effects on Ion Conduction in Ion Channels, R. Latorre, P. Labarca, and D. Naranjo. Determination of Ion Permeability by Fluorescence Quenching, A.M. Garcia. Synthetic Peptides and Proteins as Models for Pore-Forming Structure of Channel Proteins, A. Grove, T. Iwamoto, M.S. Montal, J.M. Tomich, and M. Montal. Section IV. Purification of Ion Channel Proteins and Genes: Purification and Reconstitution of Skeletal Muscle Calcium Channels, V. Florio, J. Striessnig, and W.A. Catterall. Purification and Reconstitution of Nicotinic Acetylcholine Receptor, A. Chak and A. Karlin. Purification, Affinity Labeling, and Reconstitution of a Voltage-Sensitive Potassium Channels, H. Rehm and M. Lazudunski. Affinity Purification and Reconstitution of Calcium-Activated Potassium Channels, D.A. Klaerke and P.L. J#248
• rgensen. Assay and Purification of Neuronal Receptors for Inositol 1,4,5-Triphosphate, S.R. Hingorani and W.S. Agnew. Isolation of Ion Channel Genes by Expression Cloning in Xenopus Oocytes, G.C. Frech and R.H. Joho. Hybrid Arrest Technique to Test for Functional Roles of Cloned cDNAs and to Identify Homologies among Ion Channel Genes, I. Lotan. Cloning of Ion Channel Gene Families Using the Polymerase Chain Reaction, E. Vega-Saenz De Miera and J.-W. Lin. Overview of Toxins and Drugs as Tools to Study Excitable Membrane Ion Channels I: Voltage-Activated Channels, T. Narahashi and M.D. Herman. Overview of Toxins and Drugs as Tools to Study Excitable Membrane Ion Channels II: Transmitter-Activated Channels, T. Narahashi. Biosynthesis of Ion Channels in Cell-Free and Metabolically Labeled Cell Systems, W.B. Thornhill and S.R. Levinson. Section V. Recording of Ion Channels of Cellular Organelles and Microorganisms: Patch Clamp Techniques in Study of Ion Channels from Organelles, B.U. Keller and R. Hedrich. Patch Clamp Studies of Microbial Ion Channels, Y. Saimi, B. Martinac, A.H. Delcour, P.V. Minorsky, M.C. Gustin, M.R. Culbertson, J. Adler, and C. Kung. Studies on Intact Sarcoplasmic Reticulum: Patch Clamp Recording and Tension Measurement in Lobster Split Muscle Fibers, J.M. Tang, J. Wang, and R.S. Eisenberg. Planar Bilayer Recording of Ryanodine Receptors of Sarcoplasmic Reticulum, R. Coronado, S. Kawano, C.J. Lee, C. Valdivia, and H.H. Valdivia. Section VI. Data Storage and Analysis: Software for Acquisition and Analysis of Ion Channel Data: Choices, Tasks, and Strategies, R.J. French and W.F. Wonderlin. Stationary Single-Channel Analysis, M.B. Jackson. Analysis of Nonstationary Single-Channel Currents, F.J. Sigworth and J. Zhou. Preventing Artifacts and Reducing Errors in Single-Channel Analysis, K.L. Magleby. Analysis of Drug Action at Single-Channel Level, E. Moczydlowski. Analysis of Sodium Channel Tail Currents, G. Cota and C.M. Armstrong. Calculation of Ion Currents from Energy Profiles and Energy Profiles from Ion Currents in a Multibarrier, Multisite, Multioccupancy Channel Model, O. Alvarez, A. Villarroel, and G. Eisenman. Author Index. Subject Index.

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詳細情報

• NII書誌ID(NCID): BA18376994
• ISBN:
  • 0121821080
  • 012601695X
  • 0121821943
  • 0121821951
• 出版国コード: us
• タイトル言語コード: eng
• 本文言語コード: eng
• 出版地: San Diego ; Tokyo
• ページ数/冊数: 3 v.
• 大きさ: 24 cm
• 分類:
  • DC21 : 571.64
  • NLM : W1
• 件名:
  • MESH : Electrophysiology - methods
  • MESH : Gene Expression
  • MESH : Ion Channels - chemistry
  • MESH : Ion Channels - physiology
• 親書誌ID:
  • BA00197543