The organic chemistry of drug design and drug action

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書誌事項

The organic chemistry of drug design and drug action

Richard B. Silverman

Academic Press, c1992

  • : hardcover

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

This is a new approach to the teaching of medicinal chemistry. The knowledge of the physical organic chemical basis of drug design and drug action allows the reader to extrapolate to the many related classes of drugs described in standard medicinal chemistry texts. Students gain a solid foundation to base future research endeavors upon: drugs not yet developed are thus covered!

目次

Medicinal Chemistry Folklore. Discovery of New Drugs. Drug Discovery. Design and Development. Drug Discovery. Drug Development. Lead Modification. Receptors. Receptor Structure. Drug-Receptor Interactions. Enzymes (Catalytic Receptors). Enzymes as Catalysts, Mechanisms of Enzyme Catalysis, Co-Enzyme Catalysis. Enzyme Therapy. Enzyme Inhibition and Inactivation. Why Inhibit an Enzyme? Drug Resistance, Drug Synergism (Drug Combination), Reversible Enzyme Inhibitors. Irreversible Enzyme Inhibitors. DNA. Introduction. DNA Structure and Properties. Classes of Drugs that Interact with DNA. Epilogue to Receptor-Interactive Agents. Drug Metabolism. Introduction. Synthesis of Radioactive Compounds. Analytical Methods in Drug Metabolism. Pathways for Drug Deactivation and Elimination. Prodrugs and Drug Delivery Systems. Enzyme Activation of Drugs. Mechanisms of Drug Inactivation. Index.

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