Glutathione : metabolism and physiological functions
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Bibliographic Information
Glutathione : metabolism and physiological functions
CRC Press, c1990
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Includes bibliographical references and index
Description and Table of Contents
Description
The aim of this important book is to present the reader with developments concerning glutathione research. This work focuses on the synthesis-degradation and oxidation-reduction cycles of glutathione, the physiological functions of glutathione (especially in mammalian cells), and the analytical methods used to accurately measure the glutathione status of cells. This resource addresses specific modification of glutathione metabolism that is of special interest in the treatment of some tumors. This rare volume also introduces some different, new techniques on how to accurately measure glutathione, specifically in its oxidized form. Anyone involved with biochemistry, physiology, toxicology, pharmacology, nutrition and radiation biology will find this publication interesting and filled with useful information. It is also a valuable reference for research scientists in such fields as aging, metabolism disorders, and glutathione research.
Table of Contents
Publications on Glutathione, 1983-1987, A Bibliometric Study. Determination of Tissue Glutathione. Manipulation of Liver Glutathione Status-A Double-Edged Sword. Compartmentation of Cellular Glutathione in Mitochondrial and Cytosolic Pools. Hormonal Influence of GSH Content in Isolated Hepatocytes. Glutathione Transport and Its Significance in Oxidative Stress. Glutathione and Alcohol. Glutathione in Prokaryotes. Biosynthesis and Regulation of g-Glutamyl Transpeptidase. The Role of g-Glutamyl Transpeptidase (g GTPase) in Mammary Tissue. Structure, Mechanism, Functions, and Regulatory Properties of Glutathione Reductase. Glutathione Transferase in Human Tumors and Human Cancer Cell Lines. The Formation of Disulphide Bonds in the Synthesis of Secretory Proteins: Properties and Role of Protein Disulfide-Isomerase. The Glyoxalase System: Towards Functional Characterization and a Role in Disease Processes. Glutaredoxin: Structure and Function. Glutathione and Protein Function. Role of Glutathione in the Regulation of Protein Synthesis and Degradation in Eukaryotes. Aging and Increased Oxidation of the Sulfur Pool. Glutathione Metabolism in the Mammalian Ocular Lens. Role of Glutathione in the Aging Process of the Lens. Renal Handling of Glutathione. Glutathione in Ischemia and Reperfusion-Induced Tissue Injury. Free Radicals and Thiol Compounds (The Role of Glutathione against Free Radical Toxicity). N-Acetylcysteine Stereoisomers as in vivo Probes of the Role of Glutathione in Drug Detoxification. Glutathione Levels in Human Hepatocytes Exposed to Paracetamol. Biological Implications of the Nucleophilic Addition of Glutathione to Quinoid Compounds. Glutathione and Hepatobiliary Transport of Xenobiotics. The Role of Glutathione in the Enzymatic Deiodination of Thyroid Hormone. Glutathione in Pineal Mechanisms and Functions. Nutritional Significance of Glutathione. The Potential Benefits of Dietary Glutathione on Immune Function and Other Practical Implications. Hereditary Disorders in Glutathione Metabolism. Index.
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