Human carcinogen exposure : biomonitoring and risk assessment

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書誌事項

Human carcinogen exposure : biomonitoring and risk assessment

edited by R. Colin Garner ... [et al.]

IRL Press at Oxford University Press, c1991

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注記

Papers presented at a meeting held July 1989 in Cambridge, England

Includes index

内容説明・目次

内容説明

Approximately one-third of all deaths in the western world are due to cancer, and epidemiological studies have established that environmental factors play a major role in the disease. Research on humans has so far been concentrated on statistical studies that try to link incidences of cancers to types of exposure, but this approach is only useful on a gross scale, and the results are necessarily very long in coming. Sensitive procedures are needed to assess the risks of low-level carcinogen exposure, and to determine the relative dangers of exposure to different substances. Researchers are applying the powerful tools of molecular biology to study DNA damaged by carcinogens to understand the significance of this damage at the level of the individual and its implications for risk assessment. A meeting on this subject took place in July 1989 where leading researchers presented and compared the strengths and weaknesses of various research methods, and this volume is a record of those presentations.

目次

  • PART I: A.S. Wright: Emerging strategies for the determination of human carcinogens: detection, identification, exposure monitoring, and risk evaluation
  • Kurth Randerath & Erika Randerath: The 32P-post labelling assay for DNA adducts: current status and applications to human samples
  • David E.G. Shuker: Urinalysis: review of methods
  • Paul L. Skipper & Stephen Naylor: Mass spectrometric analysis of protein-carcinogen adducts
  • Miriam C. Poirier: Immunochemical methods for assaying carcinogen-DNA adducts
  • Marja Sorsa, Sisko Salomaa, & Anneli Ojajarvi: Human biomonitoring for somatic chromosome damage
  • Mortimer L. Mendelsohn: Genetic toxicology of the human: the current status of somatic gene mutation
  • Richard J. Albertini, J. Patrick O'Neill, Janice A. Nicklas, Mark Allegretta, Leslie Recio, & Thomas R. Skopek: Molecular and clonal analysis of in vivo hprt mutations in human cells
  • William G. Thilly: Mutational spectrometry: opportunity and limitations in human risk assessment
  • Jack Cuzick: Biomonitoring: an epidemiologic perspective
  • Margareta Toernquist, D. Segerback, & L. Ehrenberg: The `rad-equivalence approach' for assessment and evaluation of cancer risks, exemplified by studies of ethylene oxide and ethene
  • PART II: WORKING GROUP REPORTS: Group 1: The relation between DNA adducts, protein adducts, and other non-target adducts
  • Group 2: What is the predictive value of DNA adducts for cancer and mutation?
  • Group 3: What is the relative sensitivity of the various biological and chemical methods for biomonitoring and carcinogen risk assessment?
  • Group 4: What are suitable experimental models? What is the relationship between animal models and man?
  • Group 5: Human studies: What needs to be done and how?
  • PART III: 27 POSTER PRESENTATIONS
  • Concluding remarks
  • Index.

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