Molecular biology of bacterial infection : current status and future perspectives : Forty-ninth Symposium of the Society for General Microbiology, held at the University of Dublin , Trinity College, September 1992
著者
書誌事項
Molecular biology of bacterial infection : current status and future perspectives : Forty-ninth Symposium of the Society for General Microbiology, held at the University of Dublin , Trinity College, September 1992
（Symposia of the Society for General Microbiology, 49）
Cambridge University Press, c1992
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注記
"Published for the Society of General Microbiology."
Includes bibliographies and index
内容説明・目次
内容説明
Understanding virulence determinants of bacterial pathogens and their regulation, and the pathogenesis of bacterial infections, is essential to the development of safe and effective vaccines and therapeutic strategies. This book presents an authoritative account of the contributions being made by molecular genetics and improved analytical technology in uncovering the molecular basis of bacteria-host interactions in infections. The broad scope of the volume encompasses normal flora and colonization resistance, evolution of pathogenic mechanisms, genetic approaches to understanding bacterial pathogenesis and in vivo studies of mutants, antigenic variation, bacterial invasion, toxins, environmental control of gene expression, regulatory networks in gene control, and attenuation of virulence through auxotrophy. The book will provide a state of the art reference for researchers in all areas concerned with bacterial infection and will also be useful as an advanced text.
目次
- 1. Normal flora and colonization resistance D. Van Der Waaij
- 2. Evolution of pathogenic mechanism M. Achtman
- 3. Genetic approaches to understanding pathogenesis of complex bacterial pathogens B. Finlay
- 4. Adhesion to and penetration of epithelial cells and intracellular behavior of invasive bacteria P. J. Sansonetti
- 5. Antigenic variation in bacterial pathogens T. F. Mayer
- 6. Capsules and LPS in invasive disease R. Moxon
- 7. Life within phagocytic cells S. H. E. Kaufmann
- 8. Bacterial latency, the carrier state and chronic infection C. Penn
- 9. Toxin-receptor interactions B. Wren
- 10. Super-antigen action of toxins R. O'Hehir
- 11. In vivo studies on mutants of pathogenic bacteria T. Foster
- 12. Toxins as delivery systems for antigens and drugs G. Dougan
- 13. Environmental control of expression of bacterial virulence determinants C. Dorman
- 14. Regulatory networks in control of expression of virulence factors in invasive bacteria G. Cornelis
- 15. Regulation of fimbrial biogenesis C. J. Smyth
- 16. Rational attenuation of bacterial pathogens S. Chatfield.
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