Biotechnology of insulin therapy
著者
書誌事項
Biotechnology of insulin therapy
（Frontiers in pharmacology & therapeutics）
Blackwell Scientific Pub, 1991
内容説明・目次
内容説明
Most experts now agree that the quality of life and freedom from complications for diabetic patients is dependent on good control of blood glucose level. This requires insulin to be administered according to the level of circulating glucose in a constantly adjustable manner. Currently, diabetics only achieve very crude control of blood glucose by injecting insulin before meals. This is far from satisfactory and a great deal of research has been undertaken to find more sophisticated methods of delivery to produce finer control of blood glucose levels and consequently reduce complications and prolong the healthy lives of diabetics. This book explains how biotechnology, i.e. the use of biological components, insulin, enzymes, genetic material and cells, can be employed to improve insulin delivery in diabetic patients.
Amongst the many techniques of biotechnology which are discussed are: recombinant DNA technology, protein and cellular engineering, gene therapy, drug modification to improve absorption across novel membranes such as the nasal and gastrointestinal mucosa and implantable insulin reservoirs, mini-pumps and enzyme biosensor electrodes for monitoring and feedback control of insulin administration. The contributors have critically reviewed these fields in a way that takes a realistic view of the possibilities and problems of new insulin delivery systems
目次
- An introduction to the problems of insulin delivery
- Human insulin and beyond: semi-synthesis and recombinant DNA technology reviewed
- Sustained-release implants for insulin delivery
- Immunoprotected islets of Langerhans as a bioartificial pancreas
- Oral insulin
- The intranasal route for insulin administration
- Glucose sensors and closed-loop insulin delivery
- Prospects for gene therapy and cellular engineering in diabetes
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