Regulation of the eukaryotic cell cycle
著者
書誌事項
Regulation of the eukaryotic cell cycle
(Ciba Foundation symposium, 170)
Wiley, 1992
大学図書館所蔵 全20件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
"A Wiley-Interscience publication."
Includes bibliographical references and indexes
"Symposium on Regulation of the eukaryotic cell cycle, held at the Ciba Foundation, London, 21-23 January 1992"
Editor: Joan Marsh
内容説明・目次
内容説明
Regulation of the Eukaryotic Cell Cycle Chairman: T. Hunter 1992 This book contains an in-depth review of the regulation of the eukaryotic cell cycle, with contributions from leading scientists in the field. The rapidly expanding family of cyclins is described for Saccharomyces cerevisiae; mouse and human homologues have been identified and their roles, especially in somatic cells, are being explored, as described here. The cyclins associate with members of another rapidly growing family, the cyclin-dependent kinases, to form the active kinase responsible for phosphorylating key substrates at defined checkpoints in the cell cycle. The book discusses the residues involved and whether the primary regulator of entry into mitosis, MPF (a cyclin/p34cdc2 complex), is phosphorylated by itself or by a different kinase. The complexity of the kinases involved in cell cycle regulation is matched by a growing number of phosphatases. The cdc25 family in Schizosaccharomyces pombe has at least ten members; three closely related homologues are known in humans and others, possibly distinct, in Drosophila.
More kinases and phosphatases have been identified in Aspergillus nidulans: there is important discussion of whether these represent pathways parallel to those known in other eukaryotes and whether homologues of genes such as nimA will be identified in yeasts and higher organisms. A major checkpoint in the cell cycle relates to the completion of DNA replication. What feature of unreplicated DNA is recognized by the regulators that govern entry into mitosis? The answer remains to be discovered, but important clues are described. Evidence linking the cell cycle with oncogenesis at the molecular level is accumulating. Chromosomal translocation and amplification of the human cyclin D1 gene locus have been found in parathyroid tumours and breast carcinomas, respectively. Expression of cyclin D genes is stimulated by growth factors, suggesting that these genes link growth factor signals with certain cell cycle transitions. The product of the c-src proto-oncogene is phosphorylated during mitosis by p34cdc2. Transcription factors such as the retinoblastoma gene product, pRb, and E1A are also found associated with and may be regulated by the cyclin-dependent kinases.
Complete elucidation of all the molecular components that control the cell cycle remains an issue for the future, but the message from this book is that much has already been learned, including the fact that it is far more complicated than was previously thought! Related Ciba Foundation Symposia: No. 150 Proto-oncogenes in cell development Chairman: T. Hunter 1990 ISBN 0 471 92686 8 No. 148 Molecular control of haemopoiesis Chairman: D. Metcalf 1990 ISBN 0 471 92561 6 No. 142 Genetic analysis of tumour suppression Chairman: E. J. Stanbridge 1989 ISBN 0 471 92299 4
目次
- Partial table of contents:
- G1 Control in Yeast and Animal Cells (S. Reed, et al.)
- Is START a Switch?
- (F. Cross & J. McKinney)
- Activation of MPF in Fission Yeast (J. Millar, et al.)
- Protein Phosphatases and Cell Division Cycle Control (M. Yanagida, et al.)
- DNA Replication and the Cell Cycle (B. Stillman, et al.)
- DNA Replication and Progression Through the Cell Cycle (M. Dasso, et al.)
- Cyclins A and B1 in the Human Cell Cycle (J. Pines & T. Hunter)
- Cell Cycle Regulation of Retinoblastoma Protein Phosphorylation (B. Lin & J. Wang)
- c-Src and Mitosis (D. Shalloway, et al.)
- Indexes.
「Nielsen BookData」 より