High density lipoproteins and atherosclerosis III : proceedings of the 3rd International Symposium on Plasma High Density Lipoproteins and Atherosclerosis, San Antonio, 4-6 March 1992
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Bibliographic Information
High density lipoproteins and atherosclerosis III : proceedings of the 3rd International Symposium on Plasma High Density Lipoproteins and Atherosclerosis, San Antonio, 4-6 March 1992
（International congress series, no. 1001）
Excerpta Medica, 1992
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Note
Includes bibliographical references and index
Description and Table of Contents
Description
Plasma high density lipoproteins (HDL) concentration is now recognized as a major independent risk factor for coronary atherosclerosis. New information on HDL metabolism has emerged in recent years which sheds light on the mechanisms which underly this association. In particular the techniques of molecular genetics and experimental pathology are being combined to explore the roles of different HDL apolipoproteins, enzymes and lipid transfer proteins in the atherogenic process. This book summarizes the important developments which have taken place in this field since the last International Symposium on the subject was held in 1988, with contributions from leading researchers. It should be of interest to all those working in the fields of lipoproteins, lipid transport, hyperlipidaemia, atherosclerosis, vascular disease, cardiology, experimental pathology and molecular biology.
Table of Contents
High density lipoprotein gene regulation. Identification of genetic loci contributing to high density lipoprotein metabolism and early atherosclerosis in a mouse model (C.H. Warden et al). Genetics of the lipoprotein lipase/apolipoprotein C-II lipolytic system: Insight from structural and evolutionary considerations (L. Chan). Apolipoprotein AI gene regulation by members of the steroid/thyroid hormone receptor superfamily of ligand dependent transcription factors (S.K. Karathanasis). Genetic variation in mouse apolipoprotein A-IV expression (K. Reue et al). Enzymes affecting high density lipoproteins. Lipase structural domains involved in HDL generation and processing (R.C. Davis and H. Wong). Cholesteryl ester transfer protein (CETP) transgenic mice: Lipoprotein metabolism and regulation of CETP gene expression (A.R. Tallet al). Molecular defects in the lecithin: Cholesterol acyltranserase gene (J.W. McLean). Regulation of the reaction of high density lipoproteins with lecithin: Cholesterol acyltransferase (A. Jonas, D.J. Bolin and F.S. Bonelli). High density lipoprotein structure. Modulation of HDL precursor structure and metabolism (A.V. Nichols, E.L. Gong and A.R. Tall). Apolipoprotein A-IV and high density lipoproteins: A tenuous interaction (R.B. Weinberg). Apolipoprotein A-I: Structure, lipid interaction and activation of lecithin: Cholesterol acyltransferase (Y.L. Marcel et al). Contribution of helix-helix interactions to the stability of apolipoprotein-lipid complexes (M. Rosseneu et al). High density lipoprotein-cell interactions. Cholesterol transport between cells and high density lipoproteins (M.C. Phillips et al). HDL receptor-mediated transport of cholesterol from cells (J.F. Oram et al). ApoA-containing lipoprotein particles: Interactions with HDL binding sites and reverse cholesterol transport (J.-C. Fruchart, G. Ailhaud and P. Denefle). High density lipoprotein-cell interactions (C.J. Fielding et al). Animal models of HDL metabolism and atherosclerosis. HDL metabolism: Studies in transgenic mice (J.L. Breslow). High density lipoprotein subpopulation distribution (S. Eisenberg). Lipoproteins and atherosclerosis in transgenic mice expressing HDL associated apolipoproteins (E. Rubin). Reverse cholesterol transport and physiology. Apolipoprotein E: Structure-function correlations (K.H. Weisgraber, S. Lund-Katz and M.C. Phillips). Mice lacking apolipoprotein A-I and tissues regulated by lipolysis of triglyceride-rich lipoproteins? (N.E. Miller). Interstitial fluid lipoprotein metabolism (P.S. Roheim et al). Human HDL metabolism and genetics. Determinants of HDL metabolism in subjects with low HDL-C levels (E.A. Brinton, S. Eisenberg and J.L. Breslow). Role of the kidney in increased clearance of apolipoprotein A-I in subjects with reduced high density lipoprotein cholesterol concentrations (B.S. Horowitz et al). Drugs, hormones and epidemiology.
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