書誌事項

In vitro methods of toxicology

Ronald R. Watson, editor

(Pharmacology & toxicology)

CRC Press, c1992

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

Current concern regarding the use of expensive animals for toxic effect testing of new drugs and old treatment agents is creating increased interest in systems that use fewer animal and human subjects. In vitro methods offer systems that can evaluate selected aspects of toxicity rapidly, cheaply, and concisely. This book examines in vitro methods for testing the toxic, pharmacological, and immunological effects of drugs. Applications for these methods are discussed, including potential benefits and pitfalls of their use. Particular emphasis is placed on key systems affected by drugs, including the heart, kidney, liver, and immune system. The potential advantages and disadvantages of these methods compared to in vivo studies are also outlined in evaluating the data.

目次

Series Preface. Preface. The Editor. Contributors. In Vitro Models for the Study of Cancer (Mary J.C. Hendrix). In Vitro Tumor Toxicity with Toxin-Antibody Conjugates (Richard D. May and R. Jerrold Fulton). Immunoglobulin Production by B Cells: In Vitro Toxicology (Francisca Martinez and John W. Coleman). Cytoxicity Assays for Intrinsic Toxicity and Irritancy (Michael Balls and Richard H. Clothier). Modulation by Drugs and Measurement of Natural Killer Cell Activity (Guan-jie Chen, Steve Wood, and Ronald R. Watson). In Vitro Measures of Mononuclear Phagocyte Functions (Guan-jie Chen, Bernhard Watzl, Dennis S. Huang, Katsuyasu Tachibana, Dennis Way, and Ronald R. Watson). An In Vitro Nephrotoxicity Assay in Renal Proximal Tubules (J.F. Sina and Matthews O. Bradley). Continuous Renal Cell Lines as In Vitro Tools to Study Nephrotoxicity (Gerhard Gstraunthaler and Walter Pfaller). Nephrotoxicity Studies with Freshly Isolated Cells From Rat Kidney (Lawrence H. Lash). Primary Proximal Tubule Cultures for Screening Nephrotoxicants (Sue M. Ford and Patricia D. Williams). The Isolated Perfused Lung Preparation (David J.P. Bassett and Robert A. Roth). The Use of Mechanical Stimulation in In Vitro Models (Louis C. Almekinders). Human Leukocytes as an In Vitro Model for Studying PCB Toxicity (Tee-Ping Lee). In Vitro Methods for Assessing Chemical or Drug Toxicity and Metabolism in Primary Hepatocytes (Nicholas J. DelRaso). In Vitro Detection of Chromosomal Aberrations (Toshio Sofuni). Measurement of Intracellular Ca2+ and pHin in Cultured Cells by Fluorescence Spectroscopy (Raul Martinez-Zaguilan). Neutral Red Assay for Toxicology In Vitro (Harvey Babich and Ellen Borenfreund). Application of Cultured Lung Cells in Toxicology (Albert P. Li and Annette G. Teepe). Evaluating In Vitro Toxicity to Mammalian Endothelial Cells (Peter Borgs, Dennis L. Way, Marlys H. Witte, Todd C. Case, Geronimo Ramirez, Jr., and Charles L. Witte).

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