Nitrosamines : toxicology and microbiology
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Bibliographic Information
Nitrosamines : toxicology and microbiology
（Ellis Horwood series in food science and technology）
Ellis Horwood, 1988
- Germany
- U.S
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Description and Table of Contents
Description
Interest in the role of N-nitroso compounds in human cancer has magnified due to the widespread use of these compounds in all branches of carcinogenesis research. Here, a knowledge of the chemistry of N-nitrosation is necessary in order to understand the association between N-nitrosamines and human disease. This book opens with a discussion of the problems associated with the analysis of volatile N-nitrosamines, of the various groups of non-volatile N-nitroso compounds and of the apparent total N-nitroso compounds. This is followed by chapters on the chemistry of N-nitroso compounds and of N-nitrosation, on the mechanisms of the endogenous formation of N-nitroso compounds and on the occurrence of N-nitroso-amines and their precursors in the human environment. The next chapter reviews the toxicology of N-nitroso compounds in animals or in vitro assay systems considering acute and chronic toxicity, carcinogenicity and teratogenicity of N-nitroso-peptides and N-nitroso bile acids. The penultimate chapter deals with the evidence implicating N-nitroso compounds in human cancer, particularly of the stomach and urinary bladder but also of other sites. The final chapter is concerned with p
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