Techniques for the genetic analysis of brain and behavior : focus on the mouse
著者
書誌事項
Techniques for the genetic analysis of brain and behavior : focus on the mouse
（Techniques in the behavioral and neural sciences, v. 8）
Elsevier, 1992
- : hb
- : pbk
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
The goal of this book is to provide a neurobehavioral context for the ever-growing list of single and multiple genes that play a role in brain structure and function. The chapters present strategies and techniques for the rigorous analysis of the genetic bases of brain and behavior, and discusses the practical and theoretical means to address these topics and provide the researcher with fine techniques for dissecting the genomic components of brain structure and behavioral function. This volume concentrates on techniques and approaches that have been largely developed with the house mouse, while providing a glimpse of genetic research with other species, such as the fruit fly, nematode worm and seaslug. Given the aim of doing genetic analysis of brain and behavior, this volume is an excellent overview of current techniques and recent innovations.
目次
Preface. List of contributors. I. The Origins of Mouse Research in Behavioural and Neural Genetics, a Personal Account. 1. Muroid roots of behaviour genetic research: a retrospective (B.E. Ginsburg). II. A Survey of Research Strategies Involving the Search for Major Genes. 2. From character to gene: some strategies for identifying single genes controlling behavioral characters (M.F.W. Festing). III. Sources of Variation. 3. Genetic diversity and evolution in the genus Mus (F. Bonhomme). 4. Some uses of inbred strains (R.E. Wimer). 5. Mouse genes with neurological effects or which affect colour (J. Peters, M.C. Kirby, Y.M. Cocking and J. Rischmiller). 6. The induction, detection and isolation of mutations (R.J. Greenspan). 7. Separating genetic effects from maternal environmental effects (M. Carlier, M. Nosten-Bertrand and C. Michard-Vanhee). 8. Genetic quality assurance (R.R. Fox). 9. Nomenclature of genetically defined mouse strains (M.F. Festing). IV. Specialized Inbred Strains. 10. The value of recombinant inbred strains in the genetic analysis od behavior (M.N. Nesbitt). 11. Congenic strains and recombinant strains - tools for genetic and functional analysis of physiological traits (P. Demant, L.F.M. van Zutphen, A.A.M. Hart and C.J.A. Moen). V. Detecting and Mapping Genes. 12. Chromosome mapping (T.H. Roderick). 13. Gene mapping techniques (J.-L. Guenet and X. Montagutelli). 14. The physical mapping of the mouse genome (S.D.M. Brown). VI. Genetic Analysis of Quantitative Phenotypes. 15. Quantitative genetics (W.E. Crusio). 16. Using quantitative genetic methods to understand mammalian circadian behavior and photoperiodism (G.R. Lynch and C.B. Lynch). VII. Analysis of the Nervous System. 17. Mouse chimeras in the study of genetic and structural determinants of behavior (D. Goldowitz, T.H. Moran and R. Wetts). 18. Hybridization analysis of nervous system gene expression (W. Wille, H. Cremer, D. Barthels and D. Goldowitz). 19. Transgenic mouse technology: applications to the study of the nervous system (E.B. Crenshaw III, L.W. Swanson, M.G. Rosenfeld and A.F. Russo). VIII. Analysis of Behavior. 20. Methodological issues in genetic analysis of an agonistic behavior (offense) in male mice (S.C. Maxon). 21. Neurological murine mutants as models for single gene effects on behavior (J.-M. Guastavino, K. Larsson and P. Jaisson). 22. Behavioral paradigms: general procedures and spatial memory (J.M. Lassalle and D. Wahlsten). 23. The problem of test reliability in genetic studies of brain-behavior correlation (D. Wahlsten). 24. Behavioral development: a tool for genetic analysis in mice (P.L. Roubertoux, M. Nosten-Bertrand, C. Cohen-Salmon and L. l'Hotellier). IX. Other Species. 25. Caenorhabditis elegans: a simple systems approach to the genetics of behavior (C.H. Rankin and C.D.O. Beck). 26. Molecular biology and function of Aplysia neuropeptides (J.R. Nambu and M.D. Kirk). 27.
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