Signal transduction : a practical approach
著者
書誌事項
Signal transduction : a practical approach
（The practical approach series）
IRL Press, c1992
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
Cellular trans-membrane signalling mechanisms are amongst the most highly studied processes in the biological sciences. G-proteins provide transduction components to allow communication between receptors for hormones and neurotransmitters and their effector systems which include enzymes involved in the generation of intracellular secondary messengers and a variety of ion channels. "Signal Transduction: A Practical Approach" details the experimental approaches which are used to define the contacts between receptors and G-proteins and between these G-proteins and their effector systems. While much emphasis in the cellular signalling field remains on the measurement of adenylyl cyclase and of phosphoinositidase C activities, it is now clear that activation of G-protein linked to receptors can also cause the regulation of phospholipases of the D and A2 classes. Thus, assays used to measure the activities of these enzyme systems are detailed in this book. The use of mutagenesis to define functional domains of G-proteins themselves has undergone considerable progress recently and examples of this approach are also provided.
This volume is designed to provide a useful guide to the newcomer to the subject, as well as allowing workers already in the field to expand the range of approaches in use in their laboratories.
目次
- Methods for the study of receptor/G-protein interaction, A. Graeser and R.R. Neubig
- basic techniques to study G-protein function, F.R. McKenzie
- reconstruction of cyc membranes by in vitro translated Gs-alpha - a model for studying functional domains of Gs-alpha subunit, Y. Audigier
- adenylate cyclase and cAMP, R.W. Farndale et al
- G-protein-mediated signal transduction - a practical approach on inositol lipids and phosphates, P.P. Godfrey
- phosphatidylcholine hydrolosis by phospholipases C and D, R.W. Bonser and N.T. Thompson
- determination of phospholipase A2 activity in stimulated cells, M.J.O. Wakelam and S. Currie
- electrophysiological approaches to G-protein function, I. McFadzean and D.A. Brown.
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