Prostacyclin : new perspectives for basic research and novel therapeutic indications : proceedings of the Symposium on Novel Perspectives in Prostacyclin Research, Vienna, Austria, 25th September 1991
著者
書誌事項
Prostacyclin : new perspectives for basic research and novel therapeutic indications : proceedings of the Symposium on Novel Perspectives in Prostacyclin Research, Vienna, Austria, 25th September 1991
（International congress series, no. 1004）
Excerpta Medica, 1992
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内容説明・目次
内容説明
This book endeavours to present an overview of the most important developments in prostacyclin research over recent years. The first part of the book deals with the three most relevant new areas of prostacyclin research: 1) analysis of novel mechanism(s) of action in "traditional" target cells (vascular smooth muscle and platelets); 2) study of the effect of prostacyclin on novel targets (e.g. endothelium), and 3) examination and potential therapeutic use of the unique cytoprotective and antiatherosclerotic properties of prostacyclin. Based on the progress made in these basic research areas the second part of the book evaluates the potential new therapeutic applications of stable prostacyclin analogues in atherosclerosis, congestive heart failure, ischemic heart disease, diabetes, pregnancy and tumor metastasis. The information summarized in this book provides an excellent reference for basic scientists and clinicians alike who are actively involved or interested in prostacyclin research and its practical application.
目次
Part I: New perspectives in basic research . Novel perspectives in prostacyclin research (G.M. Rubanyi). Molecular biology of prostacyclin biosynthesis (K.K. Wu et al.). Prostacyclin and platelets: A novel signal transduction mechanism (M. Torti, E.G. Lapetina). Prostacyclin and monocytes: Suppression of tissue factor activity procoagulant (D.J. Crutchley). Modulation of polymorphonuclear leukocyte function by prostaglandins and nitric oxide (R.J. Gryglewski, D. Salvemini). Interactions between endothelium-derived prostacyclin and nitric oxide: Molecular mechanisms and cellular effects (M. Hecker, R. Busse). Interaction of prostacyclin and endothelin (C. Thiemermann). Prostacyclin and vascular remodelling (H. Graf). Part II: Novel therapeutic indications . Novel therapeutic targets for prostacyclin analogues (J.R. Vane, R.M. Botting). Cytoprotective properties of Prostacyclin (K. Schror). Prostacyclin and atherosclerosis (M. Fredrich, B. Muller). Prostacyclin, hydroxy fatty acids and cancer metastasis (K.V. Honn, Y.Q. Chen). Prostacyclin in diabetes: Metabolism and therapeutic use (P. Rosen, D. Tschope). The potential use of prostacyclin in congestive heart failure (W.A. Long et al.). Antimetastatic properties of the stable prostacyclin analogue cicaprost (M. Schirner, M.R. Schneider). Author index.
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