Cellular immune mechanisms and tumor dormancy

著者

書誌事項

Cellular immune mechanisms and tumor dormancy

edited by Thomas H. M. Stewart, E. Frederick Wheelock

CRC Press, c1992

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

Cellular Immune Mechanisms and Tumor Dormancy features the work of internationally recognized experts from various disciplines as they discuss the phenomenon of tumor dormancy in humans. Animal models are described in which cellular and molecular components of the immune control of dormancy have been identified, and the relevance of these models to human cancer patients is recognized. Data derived from studies of organ transplantation, adjuvant chemotherapy, radiotherapy, anaesthesia, surgery, and whole blood transfusion is presented to show the vulnerability of cellular mechanisms maintaining dormancy. The potential for increasing the incidence of dormancy in micro metastases is also shown for non-small cell lung cancer, lymphoma, and leukemia. Cellular Immune Mechanisms and Tumor Dormancy is an important reference volume that will benefit researchers from many disciplines, including immunologists, pathologists, surgeons, and clinicians.

目次

  • An overview of mechanisms responsible for tumour dormancy
  • a pathologist's view of tumour dormancy
  • animal models of tumour dormancy
  • immune regulation of a murine T-cell lymphoma dormant state
  • idoptypic vaccination against B-cell lymphoma leads to dormant tumour
  • tumour dormancy in a murine lymphoma
  • amplification of natural host defense
  • mechanisms against cancer by recombinant IL-2 with induction of tumour dormancy
  • graft-versus-leukaemia effect of allogeneic bone marrow transplantation
  • late relapse and tumour dormancy
  • effects of anaesthesia on the immune response and tumour metastasis
  • the effects of anaesthesia and surgery on the immune response and tumour metastasis
  • animal studies of the effect of blood transfusion on tumour growth
  • the effect of perioperative whole blood transfusion on the outcome of cancer surgery
  • negative effects of adjuvant therapy for state I and II non small cell lung cancer
  • the effect of renal transplantation in patients with a remote history of curative cancer therapy
  • local tumour immunity and abnormal immunoregulations
  • soluble tumour antigens used in clinica trials of immunotherapy
  • evidence for the presence of dormant metastases in patients treated by adjuvant specific active immunotherapy
  • statistical analyses of clinical trials of specific active immunotherapy for non small cell lung cancer.

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