Calculation of drug lipophilicity : the hydrophobic fragmental constant approach
著者
書誌事項
Calculation of drug lipophilicity : the hydrophobic fragmental constant approach
VCH, c1992
- : Weinheim
- : New York
- タイトル別名
-
Drug lipophilicity
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注記
Spine title: Drug lipophilicity
Includes bibliographical references (p. [105]-110) and index
内容説明・目次
内容説明
Comprehensive and comparative, this "cookbook" gives the ingredients and recipes for setting up lipophilicity calculations of a great variety of organic molecules. Of particular interest is the extended presentation of the yet unpublished, revised version of the sigma f-lipophilicity calculation procedure (REKKER-system). Calculation examples of 36 drugs familiarize the user quickly with the calculation method and allow a comparative quality proof. The useful monograph unites the features of a textbook with those of a handbook for academic and industrial scientists. It gives students an exceptionally clear presentation of the subject and helps scientists save time in the laboratory.
目次
- Importance of lipophilicity in QSAR studies
- calculation of log P values
- intramolecular aspects of lipophilitic behaviour
- tables of fragmental constants
- log-P calculations for selected drugs.
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