Protein engineering : a practical approach
著者
書誌事項
Protein engineering : a practical approach
（The practical approach series）
IRL Press at Oxford University Press, c1992
- : pbk
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
Protein engineering is the rational modification or redesign of proteins using genetic engineering. Thus, it is now possible to modify enzyme specifities, remodel antibodies, and redesign many multi-domain proteins for therapeutic purposes. While the procedures for the introduction of mutations have become routine, predicting and understanding the effects of these mutations can be complicated. This volume provides a comprehensive guide to the methods used at every stage of the engineering process, from the choice of mutation strategy, through protein stability studies, to critical evaluations of mammalian, yeast, and bacterial host expression systems. It is a practical guide to this fascinating mixture of molecular biology, protein structure analysis, computation and biochemistry.
目次
- E.Y. Jones & D.I. Stuart: Methods of structural analysis of proteins - part 1 - protein crystallography
- G.M. Clore & A.M. Gronenborn: Methods of structural analysis of proteins - part 2 - nuclear magnetic resonance
- M.D.S. Boguski, J. Ostell, & D.J. States: Molecular sequence databases and their uses
- C. Sander, M. Scharf, R. Schneider: Design of protein structures
- P.A. Bates & M.J.E. Sternberg: From protein sequence to structure
- V. Daggett & P.A. Kollman: The use of theoretical methods in protein engineering
- B.E. Finn, X. Chen, P.A. Jennings, S.M. Saalau-Bethell & C.R. Matthews: Principles of protein stability - part 1 - reversible unfolding of proteins: kinetic and thermodynamic analysis
- R. Wetzel: Principles of protein stability - part 2 - enhanced folding and stabilization of proteins by suppression of aggregation in vitro and in vivo
- S. Jentsch & A. Bachmair: Principles of protein turnover: possible manipulations
- R.E. Offord: Chemical approaches to expression of proteins
- K.L. Hilyard, D. Staunton, A.E. Jones, & A.R. Rees: Protein engineering of antibody combining sites
- R.H. Jackson, J. McCafferty, K.S. Johnson, A.R. Pope, A.J. Roberts, D.J. Chiswell, T.P. Clackson, A.D. Griffiths, H.R. Hoogenboom, & G. Winter: Selection of variants of antibodies and other protein molecules using display on the surface of bacteriophage
- G.T. Yarranton & A. Mountain: Expression of proteins in prokaryotic systems - principles and case studies
- M. Kikuchi & M. Ikehara: Expression of proteins in yeast
- M. Kriegler: Genetic engineering of the processing and secretory pathway of an inflammatory cytokine in mammalian cells: a case study
- R. Bischoff, M. Courtney, & D. Speck: Industrial applications of protein engineering and scale-up of protein production: l-antitrypsin, a case study.
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