Advances in molecular and cell biology

著者

• Bittar, E. Edward

書誌事項

Advances in molecular and cell biology

editor, E. Edward Bittar

JAI Press, 1992-

• v. 4
• v. 20
• v. 21
• v. 22A
• v. 22B
• v. 23A
• v. 23B
• v. 24
• v. 25
• v. 26
• v. 27
• v. 28

注記

Publisher varies: Elsevier

内容説明・目次

巻冊次

v. 20 ISBN 9780762301416

内容説明

Cellular toxicology has entered a new era. No longer are we concerned only with necrotic cell death produced by severe, acute insult (often to multiple intracellular targets) leading to disruption of the cell membrane. New advances in molecular and cellular biology are allowing the dissection of mechanisms of cell death involving more subtle targets within the cell. Toxicology has been very important, not only in understanding the mechanisms, nature, and severity of toxicity and thereby helping in risk assessment, but toxicology has also played a very important role in helping to understand basic biological processes. Historically this has perhaps been most evident in the use of toxic agents to interfere with specific reactions in the body and hence help to dissect out the mechanisms of metabolic processes. For example, the use of chemical inhibitors was very important in understanding the process of oxidative phosphorylation, or the tricarboxylic acid cycle. More recent examples are seen herein where toxicology interfaces with, for example structural biology in the study of the cytoskeletal components and their interactions. Indirectly, an understanding of the mechanisms of endogenous protective systems also improves knowledge of basic cell biology. Toxic insult and manipulation of cell signalling and control mechanisms in cell growth and differentation also highlight how important the discipline of cell toxicity has been and will continue to be a major contributor to our understanding of basic issues in the biological and biomedical sciences. This book offers selected reviews of some of the principal molecular mechanisms of cell toxicity.

目次

Contents. List of Contributors. Introduction to Cell Toxicity: a Perspective on Intracellular Targets (J.K. Chipman). The Role of Xenobiotic Metabolism in Cell Toxicity (S. Vamvakas). Reactive Oxygen Species and their Cytotoxic Mechanisms (M.D. Evans, H.R. Griffiths, and J. Lunec). Calcium, Glutathione, and the Role of Mitochondria in Cell Injury and Death (D.J. Reed). The Cytoskeleton as a Target in Cell Toxicity (A.J. Hargreaves). Cell Death Via Interactions of Agents with DNA (J.A. Holme, R. Wiger, J.K. Honslo, E.J. Soderlund, G. Brunborg, and E. Dybing). Mechanisms of Apoptoss (A.C. Bayly, R.A. Roberts, and C. Dive). Index.

巻冊次

v. 21 ISBN 9780762301454

内容説明

The revolution in biological research initiated by the demonstration that particular DNA molecules could be isolated, recombined in novel ways, and conveniently replicated to high copy number in vivo for further study, that is, the recombinant DNA era, has spawned many additional advances, both methodological and intellectual, that have enhanced our understanding of cellular processes to an astonishing degree. As part of the subsequent outpouring of information, research exploring the mechanisms of gene regulation, both in prokaryotes and eukaryotes (but particularly the latter), has been particularly well represented. Although no one technical approach can be said to have brought the filed to its current level of sophistication, the ability to map the interactions of trans-acting factors with their DNA recognition sequences to a high level of precision has certainly been one of the more important advances. This "footprinting" approach has become almost ubiquitous in gene regulatory studies; however, it is in its "in vivo" application that ambiguities, confusions, and inconsistencies that may arise from a purely "in vitro"-based approach can often be resolved and placed in their proper perspective. Put more simply, that an interaction can be demonstrated to occur between purified factors and a particular piece of DNA in a test tube does not, of course, say anything regarding whether such interactions are occurring in vivo. The ability to probe for such interactions as they occur inside cells, with due attention paid to the relevant developmental stage, or to the tissue specificity of the interaction being probed, has made in vivo footprinting approach an invaluable adjunct to the "gene jockey's" arsenal of weapons.

目次

Contents. List of Contributors. Preface (I.L. Cartwright). A Perspective on In Vivo Footprinting (M. Nenoi and I.L. Cartwright). Genomic Sequencing by Template Purification: Principles and mapping of Protein-Bound and Single-Stranded Sequences in Vivo (J. Mirkowitch). Polymerase Chain Reaction-Aided Genomic Footprinting: Principles and Application (A.D. Riggs and G.P. Pfeifer). In Vivo Footprinting of the Interaction of Proteins with DNA and RNA (T. Grange, G. Rigaud, E. Bertrand, M. Fromont-Racine, M.L. Espinals, J. Roux, and R. Pictet). Characterization of In Vivo DNA-Protein Interactions in the Transcriptional Regulation of the Human Heat Shock Genes (L. Sistonen and R.I. Morimoto). Analysis of the Gata-1 Gene Promoter and Globin Locus Control Region Elements by In Vivo Footprinting 9E.C. Strauss and S.H. Orkin). Anazlyzing Hormone Regulation of Transcription by Genomic Footprinting (A. Reik, G. Schutz and A.F. Stewart). Photofootprinting Studies of SV40 Minichromosomes In Vivo (G.A. Grossman and M.M. Becker). Index.

巻冊次

v. 22B ISBN 9780762302833

内容説明

Recent advances in protein structural biology, coupled with new developments in human genetics, have opened the door to understanding the molecular basis of many metabolic, physiological, and developmental processes in human biology. Medical pathologies, and their chemical therapies, are increasingly being described at the molecular level. For single-gene diseases, and some multi-gene conditions, identification of highly correlated genes immediately leads to identification of covalent structures of the actual chemical agents of the disease, namely the protein gene products. Once the primary sequence of a protein is ascertained, structural biologists work to determine its three-dimensional, biologically active structure, or to predict its probable fold and/or function by comparison to the data base of known protein structures. Similarly, three-dimensional structures of proteins produced by microbiological pathogens are the subject of intense study, for example, the proteins necessary for maturation of the human HIV virus. Once the three-dimensional structure of a protein is known or predicted, its function, as well as potential binding sites for drugs that inhibit its function, become tractable questions. The medical ramifications of the burgeoning results of protein structural biology, from gene replacement therapy to "rational" drug design, are well recognized by researchers in biomedical areas, and by a significant proportion of the general population. The purpose of this book is to introduce biomedical scientists to important areas of protein structural biology, and to provide an insightful orientation to the primary literature that shapes the field in each subject. The chapters in this volume cover aspects of protein structural biology which have led to the recognition of fundamental relationships between protein structure and function.

目次

Protein Crystallography in Medicine (M.J. Rynkiewicz and B.A. Seaton). Engineering Metal Binding Sites in Proteins (L. Regan). Using Molecular Graphics to Analyze Protein Structures (H. Oberoi and N.M. Allewell). Electrostatics and Hydrogen Bonding (B. Garcia-Moreno E.). Protein Structure Determination by Nuclear Magnetic Resonance Spectroscopy (I.M. Russu). Membrane Protein Structure (M.P. McCarthy). Structural Features of Membrane Proteins (T. Haltia). Experimental Dissection of Protein-Protein Interactions in Solution (M.L. Doyle and P. Hensley).

巻冊次

v. 23B ISBN 9780762302871

内容説明

Both eukaryotic and prokaryotic cells depend strongly on the function of ion pumps present in their membranes. The term ion pump, synonymous with active ion-transport system, refers to a membrane-associated protein that translocates ions uphill against an electrochemical potential gradient. Primary ion pumps utilize energy derived from chemical reactions or from the absorption of light, while secondary ion pumps derive the energy for uphill movement of one ionic species from the downhill movement of another species. In the present volume, various aspects of ion pump structure, mechanism, and regulation are treated using mostly the ion-transporting ATPases as examples. One chapter has been devoted to a secondary ion pump, the Na+-Ca2+ exchanger, not only because of the vital role played by this transport system in regulation of cardiac contractility, but also because it exemplifies the interesting mechanistic and structural similarities between primary and secondary pumps.

目次

Preface (J.P. Andersen). Reaction Mechanism of the Sarcoplasmic Recticulum Ca2+-ATPase (H. Wolser, S. Engelender, and L. de Meis). The ATP Binding Sites of P-Type Ion Transport ATPases: Properties, Structure, Conformations, and Mechanism of Energy Coupling (D.B. McIntosh). The Gastric H+-K+-ATPase (J.M. Shin, D. Bayle, K. Bamberg and G. Sachs). Genetic Approaches to Structure-Function Analysis in the Yeast Plasma Membrane H+-ATPase (D.S. Perlin and J.E. Haber). Copper Homeostatsi by CPX-Type ATPases: The New Subclass of Heavy Metal P-Type ATPases (M. Solioz). Isosform Diversity and Regulation of Organellar-Type Ca2+-Transport ATPases (F. Wuytack, L. Raeymaekers, J. Eggermont, L. Van Den Bosch, H. Verboornen, and L. Mertens).

巻冊次

v. 24 ISBN 9780762302888

内容説明

In the past approximately quarter of a century, science has made significant progress in elucidating the skeletal elements of the cell, the extracellular matrix, cytoskeleton and nuclear matrix (i.e. the tissue matrix). While we currently know a great deal about some of the elements that comprise these structural systems, we still do not fully understand cellular structures and their relationship to cellular function. The cell is a highly ordered machine in which the skeleton provides the framework on which cellular functions take place. It is now becoming apparent that what were typically considered "soluble reactions" are rare, if existent at all. The structural systems contribute more to the cell than a framework for shape, although this is an important function. Cellular shape is reflecting what a cell is, does and will be. One can not inextricably separate cell structure and function, they go hand-in-hand.Numerous laboratories have contributed to our current understanding of the role of cell structure in cell signaling and we are now at an exciting time in this field. This volume summerizes where investigations into the role of the tissue matrix system in cellular signaling have come and to propose new directions that this research will take in the next several years. This is not meant to be complete, but hopefully will provide the reader with an overview on our current understanding of this field.

目次

Contents. List of Contributors. Preface (R.H. Getzenberg). Extracellular Matrix and Nuclear Matrix Interactions may Regulate Apoptosis and Tissue-Specific Gene Expression: A Concept whose Time has come. (S. Lelievre, V.M. Weaver, C.A. Lavabell, and M.J. Bissel). Role of the Extracellular Matrix and Cytoskeleton in the Regulation of Cyclins, Cyclin-Dependent Kinase Inhibitors, and Anchorage-Dependent Growth (R.K. Assoian, X. Zhu, G.E. Davey, and M.E. Bottazzi). Aptamer Adaptability: Utilizing Tumor Cell Surface Heterogeneity to Self-Select Appropriate Diagnostic and Therapeutic Agents (M.G. Schurmann and D.S. Coffey). Cytoskeleton-Mediated Aspects of Signal Transduction (R.M. Holmes, M.J. Carabatsos, and D.F. Albertini). The Role of the Cytoskeleton in Adhesion-Mediated Signaling and Gene Expression (a. BenZe'ev and A.D. Bershadsky). Subnuclear Trafficking of Steroid Receptors (D.B. DeFranco, J. Liu, Y. Tang, and J. Yang). The Role of Nuclear Matrix in Tissue-Specific Gene Expression (M.J. Horton and R.H. Getzenberg). Explaining Aberrations of Cell Structure and Cell Signaling in Cancer Using Complex Adaptive Systems (E.D. Schwab and K.J. Pienta). Index.

巻冊次

v. 25 ISBN 9780762303793

内容説明

The rapid expansion of the area of free radical biology in the last 25 years has occurred within a framework of assumptions and preconceived notions that has at times directed the course of this movement. The most dominant of these notions has been the view that free radical production is without exception a bad thing, and that the more efficient our elimination of these toxic substances, the better off we will be. The very important observation by Bernard Babior and colleagues in 1973 that activated phagocytes produce superoxide in order to kill micro organisms, served to illustrate that constructive roles are possible for free radicals. For many in the field, however, this merely underscored the deadly nature of oxygen-derived radicals, both from the microbe's point of view and from the host's as well. (Phagocyte-produced superoxide is responsible in part for the tissue injury manifested as inflammation. See Harris and Granger, Chapter 5, and Leff, Hybertson and Repine, Chapter 6.) Mother Nature, however, has a penchant for being able to make a silk purse from a sow's ear. If one is dealt a bad hand, one must simply make the best of it. After two decades of focusing on the destructive side of free radicals, the last few years have begun to reveal a new and finer perspective on free radical metabolism - a role in regulation of cellular function (see Schulze-Osthoff and Baeuerle, Chapter 2). Evidence from a number of sources suggests that an increase in the oxidative status of cell encourages that cell to grow and divide. Increasing the expression of mangnese superoxide dismutase can suppress the malignant phenotype of melanon cells (see Oberley and Oberley, Chapter 3). Oxidative stress beyond a certain poitosis (from the Greek, literally "to fall apart"). Is this suicide response an evolutionary fail-safe device to curtail tumorogenesis? Does oxidative stress-induced apoptosis account for the loss of immune cells in AIDS (see Flores and McCor Chapter 4)? This volume attempts to present the spectrum of roles, both good and bad played by active oxygen species as understood at this point in the evolution of this field of free radical biology.

目次

Contents. List of Contributors. Preface (J.M. McCord). An Overview of Oxyradicals in Medical Biology (I. Fridovich). Regulation of Gene Expression by Oxidative Stress (K. Schulze-Osthoff and P.A. Baeuerle). Oxyradicals and Malignant Transformation (L.W. Oberley and T.D. Oberley). Oxidative Stress and Human Immunodeficiency Virus (S.C. Flores and J.M. McCord). Neutrophils and Ischemic/Reperfusion Injury (N.R. Harris, and D.N. Granger). Oxyradicals and Acute Lung Injury (J.A. Leff, B.M. Hybertson, and J.E. Repine). Nitric Oxide Regulation of Superoxide and Peroxynitrite-Dependent Reactions (H. Rubbo and B.A. Freeman). Iron, Oxygen Radicals, and Disease (S.K. Nelson and J.M. McCord). Index.

巻冊次

v. 26 ISBN 9780762303816

内容説明

Few cells conform to the stereotype of the spherical blob hastily scribbled on chalkboards and, regrettably, sometimes even displayed prominently in textbooks. Instead, real cells display a remarkable degree of structural and functional asymmetry. In modern cell biological parlance, this asymmetry has come to be lumped under the general heading of "cell polarity". Cell polarity is by no means restricted to the cells of tissues and organs, but can also be displayed by cells that lead a more solitary existence. The amazing extent to which cell morphology is correlated with function has long been a source of inspiration for biologists. Today the fascination continues unabated in the field of cell polarity, where it is fueled by an ever-deepening appreciation for the ways that fundamental cellular processes, such as membrane trafficking and cytoskeleton assembly, contribute to the establishment and maintenance of cell polarity. In the ensuing chapters, a collection of experts will summarize and interpret the findings obtained from basic research on cell polarity in a diverse array of experimental systems.

目次

Contents. List of Contributors. Preface (J.R. Bartles). Cell Polarity in the Budding Yeast Saccharomyces Cerevisiae (C. Costigan and M. Snyder). Cell Polarity and mouse early Development (T.P. Fleming, E. Butler, J. Collins, B. Sheth, and A.E. Wild). Signals and Mechanisms of Sorting in Epithelial Polarity (C.J. Gottardi and M.J. Caplan). The Generation of Polarity in Neuronal Cells (S.K. Powell and R.J. Rivas). Polarity and Development of the Cell Surface in Skeletal Muscle (A.O. Jorgensen). Polarity and Polarization of Fibroblasts in Culture (A.K. Harris). Index.

巻冊次

v. 27 ISBN 9780762303878

内容説明

This volume brings together a set of reviews that provide a summary of our current knowledge of the proteolytic machinery and of the pathways of protein breakdown of prokaryotic and eukaryotic cells. Intracellular protein degradation is much more than just a mechanism for the removal of incorrectly folded or damaged proteins. Since many short-lived proteins have important regulatory functions, proteolysis makes a significant contribution to many cellular processes including cell cycle regulation and transciptional control. In addition, limited proteolytic cleavage can provide a rapid and efficient mechanism of enzyme activation or inactivation in eukaryotic cells.In the first chapter, Maurizi provides an introduction to intracellular protein degradation, describes the structure and functions of bacterial ATP-dependent proteases, and explores the relationship between chaperone functions and protein degradation. Many of the principles also apply to eukaryotic cells, although the proteases involved are often not the same. Interestingly, homologues of one of the bacterial proteases, Ion protease, have been found in mitochondria in yeast and mammals, and homologues of proteasomes, which are found in all eukaryotic cells (see below), have been discovered in some eubacteria. Studies of proteolysis in yeast have contributed greatly to the elucidation of both lysosomal (vacuolar) and nonlysosomal proteolytic pathways in eukaryotic cells. Thumm and Wolf (chapter 2) describe studies that have elucidated the functions of proteasomes in nonlysosomal proteolysis and the contributions of lysosomal proteases to intracellular protein breakdown. Proteins can be selected for degradation by a variety of differen mechanisms. The ubiquitin system is one complex and highly regulated mechanism by which eukaryotic proteins are targetted for degradation by proteosomes. In chapter 3, Wilkinson reviews the components and functions of the ubiquitin system and considers some of the known substrates for this pathway which include cell cycle and transcriptional regulators. The structure and functions of proteosomes and their regulatory components are described in the two subsequent chapters by Tanaka and Tanahashi and by Dubiel and Rechsteiner. Proteasomes were the first known example of threonine proteases. They are multisubunit complexes that, in addition to being responsible for the turnover of most short-lived nuclear and cytoplasmic protein, are also involved in antigen processing for presentation by the MHC class I pathway. Recent studies reviewed by McCracken and colleagues (chapter 6) lead to the exciting conclusion that some ER-associated proteins are degraded by cytosolic proteasomes. Lysosomes are responsible for the degradation of long-lived proteins and for the enhanced protein degradation observed under starvation conditions. In chapter 7 Knecht and colleagues review the lysosomal proteases and describe studies of the roles of lysosomes and the mechanisms for protein uptake into lysosomes. Methods of measuring the relative contribution of different proteolytic systems (e.g., ubiquitin-proteasome pathway, calcium-dependent proteases, lysosomes) to muscle protein degradation, and the conclusions from such studies, are reviewed by Attai and Taillinder in the following chapter. Finally, proteases play an important role in signaling apoptosis by catalyzing the limited cleavage of enzymes. Mason and Beyette review the role of the major players, caspases, which are both activated by and catalyze limite proteolysis, and also consider the involvement of other protoelytic enzymes in this pathway leading cell death.

目次

Contents. List of Contributors. Preface (A.J. Rivett). Biochemical Properties and Biological Functions of ATP-Dependent Proteases in Bacterial Cells (M.R. Maurizi). From Proteasome to Lysosome: Studies on Yeast Demonstrate the Principles of Protein Degradation in the Eukaryote Cell (M. Thumm and D.H. Wolf). Cellular Regulation by Ubiquitin-Dependent Processes (K.D. Wilkinson). The 20s Proteasome: Subunits and Functions (K. Tanaka and N. Tanahashi). The 19s Regulatory Complex of the 26s Proteasome (W. Dubiel and M. Rechsteiner). Endoplasmic Reticulum0Associated Protein Degradation: an Unconventional Route to a Familiar Fate (A.A. McCracke, E.D. Werner, and J.L. Brodsky). Pathways for the Degradation of Intracellular Proteins within Lysosomes in Higher Eukaryotes (E. Knecht, J.J.M. de Llano, E.J. Andreu, and I.M. Miralles). The Critical Role of the Ubiquitin-proteasome Pathway in Muscle Wasting in Comparison to Lysosomal and Ca2+-dependent Systems (D. Attaix and D. Taillandier). Proteolysis in Apoptosis: Enzymes and Substrates (G.G.F. Mason, and J. Beyette). Index.

巻冊次

v. 28 ISBN 9780762304950

内容説明

The aim of "The Adhesive Interaction of Cells" has been to assemble a series of reviews by leading international experts embracing many of the most important recent developments in this rapidly expanding field. The purpose of all biological research is to understand the form and function of living organisms and, by comprehending the normal, to find explanations and remedies for the abnormal and for disease conditions. The molecules involved in cell adhesion are of fundamental importance to the structure and function of all multicellular organisms. In this book, the contributors focus on the systems of vertebrates, especially mammals, since these are most relevant to human disease. It would have been equally possible to concentrate on developmental processes and adhesion in lower organisms. A major function of adhesion molecules is to bind cells to each other or to the extracellular matrix, but they are much more than "glue". Adhesions in animal tissues must be dynamic-forming, persisting, or declining in regulated fashion- to facilitate the mobility and turnover of tissue cells. Moreover, the majority of adhesion molecules are transmembrane molecules and thus provide links between the cells and their surroundings. This gives rise to another major function of adhesion molecules, the capacity to transduce signals across the hydrophobic barrier imposed by the plasma membrane. Such signal transduction is crucially important to many aspects of cellular function including the regulation of cell motility, gene expression, and differentiation. The work in this book progresses through four sections. Part I discusses the four major families of adhesion molecules themselves, the integrins (Green and Humphries), the cadherins (Stappert and Kemler), the selectins (Tedder et al.) and the immunoglobulin superfamily (Simmons); part 2 considers junctional complexes involved in cell interactions: focal adhesions and adherens junctions (Ben Ze'ev), desmosomes (Garrod et al.), and tight junctions (Citi and Cordenonsi). The signaling role of adhesion molecules is the focus of part 3, through integrins and the extracellular matrix (Edwards and Streuli), through platelet adhesion (Du and Ginsberg), and in the nervous system (Hemperley). In part 4, the aim is to show how adhesive phenomena contribute to important aspects of cell behavior and human health. Leukocyte trafficking (Haskard et al.), cancer metastasis (Marshall and Hart), cell migration (Paleck et al.), and implantation and placentation (Damsky et al.) are the topics considered in depth. The different sections are, of course, not mutually exclusive: it is both undesirable and impossible to separate structure from function when considering cell adhesion. Each chapter has its unique features, but some overlap is both invevitable and valuable since it provides different perspectives on closely related topics. We hope that the whole contributes a valuable and stimulating consideration of this important topic.

目次

Contents. List of Contributors. Preface (D.R. Garrod). Part I Adhesion Molecules and their Ligands. The Molecular Anatomy of Integrins (L.J. Green and M.J. Humphries). The Cadherin Superfamily (J. Stappert and R. Kemler). The Selectins and their Ligands: Adhesion Molecules of the Vasculature (T.F. Tedder, X. Li, and D.A. Steeber). The Immunoglobulin Superfamily (D.L. Simmons). Part II. Organization of Adhesion Complexes. Focal Adhesions and Adherens Junctions: their Role in Tumorigenesis (A. Ben-Ze'ev). Desmosomal Adhesion (D.R. Garrod, C. Tselepis, S.K. Runswick, A.J. North, S.R. Wallis, and M.A.J. Chidgey). The Molecular Basis for the Structure, Function, and Regulation of Tight Junctions (S. Citi and M. Cordenonsi). Part III Signaling by Adhesion Molecules. Activation of Integrin Signaling Pathways by Cell Interactions with Extracellular Matrix (F.M. Edwards and C.H. Streuli). Signaling and Platelet Adhesion (X. Du and M.H. Ginsberg). Signaling by Cell Adhesion Molecules in the Nervous System (J.J. Hemperly). Part IV Adhesive Processes. Vascular Endothelial Cell Adhesion Molecules and the Control of Leukocyte Traffic in Cutaneous Inflammation (D.O. Haskard, J.C. Mason, and J. McHale). The Role of Adhesion in Metastasis: Potential Mechanisms and Modulation of Integrin Activity (J.F. Marshall and I.R. Hart). Integrin Adhesion in Cell Migration (S.P. Palecek, E.A. Cox, A. Huttenlocher, D.A. Lauffenburger, and A.F. Horwitz). Adhesion Receptors: Critical Effectors of Trophoblast Differentiation during Implantation and Placentation (C.H. Damsky, Y. Zhou, O. Genbacev, J. Cross, and S.J. Fisher). Index.

巻冊次

v. 4 ISBN 9781559382090

内容説明

The fourth volume of the "Advances in Molecular and Cell Biology" series. Cell biology is a rapidly-developing discipline, bringing together many separate biological sciences. The interrelations of cell structure and function at molecular and subcellular levels are the central theme of the series.

目次

Contents. List of Contributors. Preface (E.E. Bittar). The Centromere (J.B. Rattner and A.K.C. Wong). The Nuclear Matrix: Structure, Function and DNA Replication (R. Berezney). Functional Aspects of Chromosome Organization: Scaffold Attachment Regions and their Ligands (S.M. Gasser). Signal Transduction to the Cell Nucleus (E.A. Nigg). The Peroxisome: Organization and Dynamics (C. Masters and D. Crane). The Endoplasmic Reticulum (G.L.E. Koch). Dynamics of the Interphase Golgi Apparatus in Mammalian Cells (B. Storrie). Role of Autophagy in Hepatic Macromolecular Turnover (G.E. Mortimore). Lysosomal Acidity (D.L. Schneider and J. Chin). The Ribosome: Function, Organization and Structure (R. Brimacombe). Index.

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詳細情報

• NII書誌ID(NCID): BA19149739
• ISBN:
  • 1559382090
  • 0762301414
  • 0762301457
  • 0762302836
  • 0762302836
  • 0762302879
  • 0762302879
  • 0762302887
  • 0762303794
  • 0762303816
  • 0762303875
  • 0762304952
• 出版国コード: us
• タイトル言語コード: eng
• 本文言語コード: eng
• 出版地: Greenwich, Conn.
• ページ数/冊数: v.
• 大きさ: 24 cm