Iron and human disease

著者

書誌事項

Iron and human disease

edited by Randall B. Lauffer

Tokyo : CRC Press, c1992

大学図書館所蔵 件 / 全3件

この図書・雑誌をさがす

注記

Includes bibliographical references and index

内容説明・目次

内容説明

Iron and Human Disease is the first book to cover the three key aspects of human iron metabolism: the accumulation of iron in adults, iron as a limiting factor for tumor and infectious cell growth, and iron as a catalyst for oxygen free radical production. The book describes the hypotheses and findings related to the role of iron in cardiovascular disease (including reperfusion injury), cancer, aging, and autoimmune and neurodegenerative diseases. Other topics covered include the molecular biology and biochemistry of iron, the general principles governing iron balance, iron in the immune system and acute phase response, and new preventive and therapeutic strategies. Iron and Human Disease will be a useful reference for biomedical investigators, physicians, nutritionists, and public health officials.

目次

Introduction. Iron, Aging, and Human Disease: Historical Background and New Hypotheses (R.B. Lauffer). Chemistry and Molecular Biology of Iron and Iron-Binding Proteins: Structure and Molecular Biology of Iron-Binding Proteins and the Regulation of 'Free' Iron Pools (R.R. Crichton and R.J. Ward). Genetic Control of the Genes for Iron Storage and Transport: Links with the Acute Phase Response (J.T. Rogers). Iron Accumulation and METABOLISM in Humans: Iron Balance in Western Societies as Measured by Serum Ferritin (J.W. Halliday and B.A. Leggett). Hereditary Hemochromatosis and Other Diseases Associated with Iron Overload (J.W. Halliday and L.W. Powell). Iron and the Immune System (J.H. Brock). Cellular Acquisition of Iron and the Iron withholding Defense Against Microbial and Neoplastic Invasion (E.D. Weinberg). Iron and Oxidative Stress: Iron and Damage to Biomolecules (B. Halliwell). Lipofuscin, Lysosomes, and Iron (U.T. Brunk, M.R. Marzabadi, and C.B. Jones). Roles for Iron in Cardiovascular Diseases: Role of Iron in the Oxidative Modification of Low Density Lipoprotein (S. Parthasarathy). Iron and Myocardial Reperfusion Injury (J.L. Zweier). Stored Iron as a Risk Factor for Ischemic Heart Disease (J. Sullivan). Iron and Stroke (L.S. Terada, I.R. Willingham, and J.E. Repine). Roles for Iron in Other COmmon Diseases: Iron and Cancer (R.G. Stevens). Brain Iron and Nigra-Striatal Dopamine Neurons in Parkinson's Disease (D. Ben-Shachar, and M. Youdim). Proteins of Iron Regulation in Alzheimer's Disease (J.R. Connor). Iron-Promoted Oxidative Damage in Rheumatic Diseases (C.W. Trenam, P.G. Winyard, C.J. Morris, and D.R. Blake). Iron and Ethanol-Induced Tissue Damage (A.I. Cederbaum). Iron Metabolism and Oxygen Radical Injury in Premature Infants (J. Sullivan). Implications for Prevention and Therapy: Preventive Measures for the Maintenance of Low But Adequate Iron Stores (R.B. Lauffer). Therapeutic Strategies to Inhibit Iron-Catalyzed Tissue Damage (B. Hedlund and P.E. Hallaway) Iron and Oxidative Balance (J. McCord).

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