Cell transformation and radiation-induced cancer
著者
書誌事項
Cell transformation and radiation-induced cancer
（EUR, 12248）
Adam Hilger, c1989
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注記
"Proceedings of a workshop jointly organised by the Nuclear Energy Board of Ireland, the United States Department of Energy, and the Commission of the European Communities, held in Dublin, Ireland, on 4-7 April 1989"--P. facing t.p
Includes bibliograpical references and index
内容説明・目次
内容説明
The transformation of mammalian cells in vitro provides quantitative and qualitative information on the processes by which physical and chemical agents induce malignancy. Recently, there has been considerable progress on the developmnent of new cell transformation systems and the role of oncogenes in cell transformation. An International Workshop held during April 1989 in Dublin encouraged collaborative interactions between the scientists working in this field and provided a forum for critical review of current research results. Cell Transformation and Radiation-induced Cancer is a record of the papers presented at the Workshop. It includes work which focuses on the potential of emerging human cell transformation systems and their relevance to radiation carcinogenesis, and on the role and interplay of oncogenes, retroviruses and radiation in cell transformation. Particular emphasis is placed on the influence of such variables as radiation quality, dose and dose rate, promoters and suppressors and cell types on in vitro cell transformation. Also considered are the implications of the results from cell transformation studies for radiation-induced cancer in man and for radiological protection. This book will be of interest to molecular biologists, medical physicists and cancer specialists who require a comprehensive account of the latest work on cell transformation and radiation-induced cancer.
目次
Pathology, invasiveness, apoptosis (3 papers). Immortalisation and transformation of human and mammalian cells (11 papers). In-vivo/in-vitro transformation systems (3 papers). Chromosomal rearrangements and mutations in cancer (8 papers). Oncogenes and retroviruses (5 papers). Initiation, promotion and interaction (5 papers). Molecular lesions and cell transformation (2 papers). Dose-effect relationships (8 papers). Cell transformation, cancer and risk (2 papers). Final commentary. Author index.
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