Cancer chemotherapy
著者
書誌事項
Cancer chemotherapy
（Frontiers in pharmacology & therapeutics）
Blackwell Scientific Publications, 1993
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
Cancer treatment is one of the most difficult and complex challenges to face pharmacology. Existing drugs produce results only at the expense of severe side effects such as hair loss, nausea and vomiting and are fairly unsuccessful against solid tumours. Intensive research is currently underway to find agents which will be both more effective and less distressing to the patient. This book critically reviews the latest developments in the field of anticancer drugs, in particular the discovery of new targets and sites of action of new chemotherapy agents.
目次
- The promise of oncogene inhibitors as novel antitumour agents
- apoptosis and cancer chemotherapy
- the cytoskeleton as a chemotherapeutic target
- tyrphostins - a novel concept for antiproliferative drugs
- neuropeptide growth factors and antagonists
- ether lipids in experimental cancer chemotherapy
- the role of protein kinase C and protein phosphorylation in multidrug resistance
- resistance to topoisomerase II-directed anticancer agents
- mammalian DNA topoisomerase I and its inhibitors
- DNA sequence specificity of anticancer agents
- mechanism of sequence-specific oxidative DNA damage by neocarzinostatin and other enediyne containing antitumour antibiotics
- tumour endothelium as a target for solid tumour therapy
- pharmacological approaches to the management of metastatic prostatic cancer
- cytokines in haemopoiesis - their application in oncology.
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