Drug stereochemistry : analytical methods and pharmacology
著者
書誌事項
Drug stereochemistry : analytical methods and pharmacology
（Clinical pharmacology, v. 18）
M. Dekker, c1993
2nd ed., rev. and expanded
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
Maintaining and enhancing its focus on key issues in the development, regulatory approval and use of stereoisomeric compounds, this edition continues to cover in detail all aspects of chiral drugs from the academic, governmental, industrial and clinical points of view.;Completely rewritten and updated throughout, Drug Stereochemistry: illustrates current indirect chromatographic methods for the resolution of drug enantiomers; treats the rapidly growing area of enantioselective gas chromatography; discusses the latest in HPLC resolution of enantiomeric drugs; uses verapamil as a model to show how stereoselective pharmacokinetics affect pharmacodynamics; and supplies an in-depth study on the effect of stereoselective plasma protein binding.;This edition offers entirely new chapters that: discuss the recent decisions and present position of the US Food and Drug Administration on the development of stereoisomeric drugs; explicate enzymatic synthesis of stereochemically pure drugs; review the toxicological, pharmacokinetic and pharmacodynamic differences found among stereoisomers; elucidate the stereoselective transport of drugs across epithelia; and give a physician's perspective on the questions and problems caused by stereoisomeric drugs in practice as well as the pharmaceutical industry's collective viewpoint based on a national survey.
目次
- Part 1 Introduction: The early history of stereochemistry - from the discovery of molecular asymmetry and the first resolutionof a racemate by pasteur to the asymmetrical carbon of Van't Hoff and Le Bel, Dennis E. Drayer
- stereochemical terms and concepts - an overview, Irving W. Wainer and Alice A. Marcotte. Part 2 The separation and preparation of stereochemically pure drugs: enantiomer analysis by competitive binding methods, C. Edgar Cook
- indirect methods for the chromatographic resolution of drug enantiomers synthesis and separation of diastereomeric derivatives, Joseph Gal
- the direct resolution of enantiomeric drugs by chiral-phase gas chromatography, Wilfried A. Koenig
- HPLC chiral stationary phases for the stereochemical resolution of enantiomeric compounds - the current state of the art, Irving W. Wainer
- synthesis of enantiomerically pure drugs, John W. Scott
- enzymatic synthesis and resolution of enantiomerically pure compounds, David I. Stirling. Part 3 Pharmacokinetic and pharmacodynamic differences between drug stereoisomers: stereoselective biotransformation toxicological consequences and implications, Nico P.E. Vermeulen and Johan M. te Koppele
- stereoselective transport of drugs across epithelia, Ronda J. Ott and Kathleen M. Giacomini
- verapamil - a chiral challenge to the pharmacokinetic and pharmacodynamic assessment of bioavailability and bioequivalence, James A. Longstreth
- enantioselective binding of drugs to plasma proteins, Terence A.G. Noctor. Part 4 Perspectives on the use of stereochemically pure drugs: FDA perspective on the development of new stereoisomeric drugs - chemistry, manufacturing, and control issues, Wilson H. de Camp
- stereochemically pure drugs - an overview, Fakhreddin Jamali
- stereoisomeric drugs in therapeutics - clinical perspectives, Darrell R. Abernathy and Nabil S. Andrawis
- development of stereoisomeric drugs - an industrial perspective, Mitchell N. Cayen.
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