The pharmacology of cell differentiation : proceedings of the Esteve Foundation Symposium V, Son Vida, Mallorca, 12-15 October, 1992
著者
書誌事項
The pharmacology of cell differentiation : proceedings of the Esteve Foundation Symposium V, Son Vida, Mallorca, 12-15 October, 1992
（Esteve Foundation symposia, v. 5）（International congress series, no. 1016）
Excerpta Medica, 1993
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内容説明・目次
内容説明
The symposium on "The Pharmacology of Cell Differentiation", upon which this text is based, has been structured to begin with an exploration, first of general, then more specific mechanisms implicated in the inter- and intra-cellular systems exploited by cells for the transduction of growth and developmental signals; then to examine the intracellular machinery for cell growth regulation, the gene-expression control mechanisms identified in transformed and normal cells; and finally to move to selected examples illustrating the exploitation of these findings for the induction of developmental changes in real cancers. This is not a review of established successes in cancer therapy; rather it is a progress report on work on-going at one of the frontiers of contemporary pharmacology.
目次
Part 1 Signalling: General mechanisms - Signal transduction by the mitogenic phospholipid, lysophosphatidic acid (W.H. Moolenaar et al.). The roles of specific isoforms of protein kinase C (PKC) in growth control, oncogene-induced cell transformation, and differentiation (I.B. Weinstein et al.). Role of Ras proteins in T cell activation (J. Downward). Part 2 Signalling: Growth factors and receptors. TGF-B and myogenesis: Interference with cell cycle G1, phase progression may lead to differentiation (A. Zentella, J. Massaugue). Role of MAP kinases in the control of cell proliferation (G. Pages et al.). The erythropoietin receptor - Structure, activation and tumourigenesis (H.F. Lodish). The kit-ligand (steel factor) and it's receptor c-kit: Pleiotropic roles in cell growth, cell survival and cell migration - Insights from germline mutations (P. Besmer et al.). Part 3 Cell cycle control mechanisms and tumour suppressors. Switching genes on at the start of the yeast cell cycle (S. Sockanathan et al.). Mechanisms of action of p53 (Y. Barak et al.). The role of tumor suppressor genes in cancer and development (L. Fiszer-Maliszewska, S.H. Friend). Part 4 Regulation of gene expression. Effects of myc expression on mouse myoblasts are reversed in mixed culture with normal cells (M. Crescenzi, D. Crouch, F. Tato). Id as a general negative regulator of the Helix-Loop-Helix family of DNA-binding proteins (R. Benezra). Molecular genetics of acute promyelocytic leukemia: The t(15,17) translocation (H. de The et al.). Retinoic acid and human teratocarcinoma differentiation (J.M. Kurie, E. Dmitrovsky). Part 5 Differentiation inducing agents. Induced differentiation: Molecular mechanism and therapeutic potential (R.A. Rifkind, P.A. Marks). Vitamin D3 analogs and hematopoiesis (Y. Imai, P. Koeffler). The design of differentiation therapies (G.E. Francis). Synergism between differentiation agents: Preclinical and clinical studies in myeloid leukaemia (H.T. Hassan).
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