Medicinal chemistry : the role of organic chemistry in drug research
著者
書誌事項
Medicinal chemistry : the role of organic chemistry in drug research
Academic Press, c1993
2nd ed
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
This Second Edition covers exciting progress recently made with individual drugs and includes a special chapter on the impact of molecular biology on drug design. Other additions to the Second Edition include structure-activity relationships, the role of molecular biology in drug discovery, and drug access and prodrugs. Written for students considering a research career in drug development, this volume is conveniently divided into two parts. The first half introduces readers to the mechanisms of action of drugs and the approaches adopted in designing new drugs. The second half contains chapters written by the discoverers or developers of individual successful drugs who trace the history of the drugs to the present day.
目次
1. Introduction to Receptors and the Action of Drugs
2. Structure and Atalytic Properties of Enzymes
3. Receptor Pharmacology
4. Drug Access and Prodrugs
5. QSAR and the Role of Computers in Drug Design
6. The Current Status and Future Impact of Molecular Biology in Drug Discovery
7. General Approaches to Discovering New Drugs: An Historical Perspective.
8. Discovery and Development of Cromakalim and Related Potassium Channel Activators
9. Angiotension-Converting Enzyme (ACE) inhibitors and the Design of Cilazapril
10. Beta Blockers
11. Salbutamol: A Selective B2-Stimulant Bronchodilator
12. Discovery of CCimetidine, Ranitidine and Other H2-Receptor Histamine Antagonists
13. Fluconazole, An Orally Active Antifungal Agent
14. Clavulanic Acid and Related Compounds: Inhibitors of B-Lactamase Enzymes
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