PET studies on amino acid metabolism and protein synthesis : proceedings of a workshop held in Lyon, France within the framework of the European Community medical and public health research
著者
書誌事項
PET studies on amino acid metabolism and protein synthesis : proceedings of a workshop held in Lyon, France within the framework of the European Community medical and public health research
(Developments in nuclear medicine, 23)
Kluwer Academic Publishers, c1993
大学図書館所蔵 全7件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes bibliographical references and index
内容説明・目次
内容説明
Parameters such as membrane transport, metabolism and protein incorporation govern the fate of amino acids in living tissue. Is it possible to use positron tomography to measure some of them, and what is their meaning in normal and pathological situations? These questions have been addressed for a long time and no satisfactory answer has yet been given. This book, which derives from an EEC workshop organized in the frame of the Concerted Action on "PET Investigation of Cellular Regeneration and Degeneration", held in Lyon in February 1992, gives the present state of knowledge in this field based on the most recent studies. Contributions from 24 leading European and American scientists are presented and discussed.
目次
- Part 1 Biochemistry and animal studies: cerebral protein turnover - aspects and problems
- determination of regional rates of cerebral protein synthesis in vivo with L-{1-14C} Leucine as the tracer amino acid
- methionine metabolism in rat brain
- protein synthesis studies in rats with methionine
- discussion. Part 2 PET radiochemistry: carbon-11 amino acids, labelling and metabolites
- quality control aspects in the preparation of {11C}-methionine
- production of L-{18F)fluro amino acids for protein synthesis - overview and recent developments in nucleophilic syntheses
- biochemistry and evaluation of fluoramino acids
- discussion. Part 3 Amino acid uptake modelling: kinetic modelling of fluorotyrosine uptake
- kinetic modelling of carbon-11 labelled amino acids
- carbon-11 labelled tyrosine as a probe for modelling the protein synthesis rate
- kinetic modelling of carbon-ll labelled methionine
- approaches to quantitative analysis of amino acid transport and metabolism
- 11 C-methionine and rubidium uptake in human brain tumours - comparison of carrier dependent blood-brain barrier transport
- discussion. Part 4 Clinical applications: tracers for clinical evaluation of gliomas - a neurologist's view
- PET studies of amino acid metabolism - integration in clinical routine and current research on intracranial tumours
- uptake of {11C} methionine in non-brain tumours
- utilization of amino acid transport rates for the differential diagnosis of brain tumours
- use of amino acid uptake and protein synthesis rates for tumour diagnosis
- 11C-methionine uptake in brain tumours measured by PET - early clinical results
- 11C-labelled methionine uptake in gliomas - modification after therapy and metabolic correlations
- in vivo incorporation of labelled methionine into proteins in brain tumours.
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