Renal cell carcinoma : immunotherapy and cellular biology
著者
書誌事項
Renal cell carcinoma : immunotherapy and cellular biology
Marcel Dekker, 1993
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
This reference brings together all aspects of renal cell carcinoma, and provides a basis for understanding the disease's origin, progression and responses to immunotherapy.;Examining the current status of cytokine, cell-based and chemotherapeutic methods of treatment, this book: discusses the clinical presentation of advanced renal carcinoma and its therapeutic challenges; reviews prognostic factors and the management of renal cell carcinoma occurring with von Hippel-Landau syndrome; summarizes efforts to identify the tumour suppressor gene deleted from chromosome 3 in most renal cell carcinomas; explicates the role of oncogenes in the progression of renal cell cancer and the molecular correlates of responses to interferon-alpha treatment; details the latest laboratory efforts to establish gene therapy for tumour treatment by transfection of cytokine genes in murine model systems; focuses on biologic response modifier therapy in humans, including cell-mediated immune responses and adoptive immunotherapy; presents preclinical and clinical studies of interleukin-2 alone, in combination with othe cytokines, and with chemothrapeutic agents; and addresses studies on the tumour necrosis factor and low- and high-dose interferon-alpha.
目次
- The challenge of advanced renal cell carcinoma
- clinical features
- molecular biology
- cell-mediated immune responses and adoptive immunotherapy
- interleukin-2 and other cytokines
- combination therapy with cytokines
- chemotheray and chemoimmunotherapy
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