Aspirin and other salicylates
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Bibliographic Information
Aspirin and other salicylates
Chapman & Hall Medical, 1992
1st ed
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Includes bibliographical references and index
Description and Table of Contents
Description
Aspirin has the advantages of being inexpensive to buy and available without the need of a doctor's prescription. It is the most widely used drug in the world thanks partly to its relative lack of toxicity and low addictive. Of no less importance than its use as a drug have been the advances aspirin has made possible in the fields of physiology and medicine as a result of the unravelling of its mechanism of action. The elucidation of the mechanism of action of aspirin also allowed the rational development of new therapeutic agents with similar activity to add to the non-steroidal anti-inflammatory drugs already found by empirical means. This book deals in a comprehensive way with the pharmacology of aspirin and the scientific discoveries made possible by the use of aspirin and aspirin-like drugs.
Table of Contents
- Part 1 Introduction, J.R. Vane and R.M. Botting: history of aspirin and the salicylates
- the prostaglandins
- mechanism of action of aspirin and salicylates. Part 2 Pharmacokinetics of aspirin and salicylates: is aspirin a pro-drug for salicylate?, G.A. Higgs and J.A. Salmon
- aspirin - pharmacokinetics and pharmacodynamic effects on platelets and vascular function, W.N. Charman, et al
- differential pharmacokinetics of different salicylates, K. Dietzel and K. Brune. Part 3 Pharmacology of aspirin and salicylates: anti-inflammatory actions, R.J. Flower and D.A. Willoughby
- aspirin and analgesia, J.R. Vane and R.M. Botting
- antipyretic actions of aspirin, A.S. Milton
- anti-thrombotic actions of aspirin, J.R. Vane, et al. Part 4 Therapeutic applications: use of aspirin in inflammatory diseases, E.C. Huskisson
- aspirin and myocardial infarction with an annotation on venous thrombosis, T.W. Mead
- aspirin in ischemic stroke, W.S. Fields and F. Clifford-Rose
- the effect of aspirin in headaches and migraine, P.T.G. Davies and F. Clifford-Rose
- unstable angina, J.A. Cairns
- the use of aspirin in grafts, H. Sinzinger, et al
- pre-eclampsia and intra-uterine growth retardation, M. de Swiet. Part 5 Unwanted effects: gastro-intestinal tract, B. Whittle
- renal effects of aspirin, E.J. Zambraski and M.J. Dunn
- Reye's syndrome and aspirin, A.P. Mowat
- aspirin-induced asthma, A. Szczeklik
- other unwanted side effects and drug interactions with aspirin and other salicylates, M. Kurowski and K. Brune.
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