Trends in drug research : proceedings of the seventh Noordwijkerhout-Camerino Symposium, Noordwijkerhout, The Netherlands, 5-8 September 1989
著者
書誌事項
Trends in drug research : proceedings of the seventh Noordwijkerhout-Camerino Symposium, Noordwijkerhout, The Netherlands, 5-8 September 1989
(Pharmacochemistry library, v. 13)
Elsevier , Elsevier Science Pub. Co., 1990
大学図書館所蔵 全3件
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  愛知
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  京都
  大阪
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  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
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  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
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  韓国
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
This volume comprises the invited lectures of the Seventh Noordwijkerhout-Camerino Symposium. The authors of the 28 papers give a detailed account of recent advances in the fields of receptor-drug interactions, structure-activity relationships, molecular toxicology, drug targeting, peptidergic drugs, inhibitors of cholesterol biosynthesis, antimalarial and antileprosy drugs. Containing up-to-date surveys of recent trends in synthetical and biological investigations in drug design, this volume should prove invaluable to medicinal chemists and to pharmacologists and toxicologists working in the field of drug design and development.
目次
- Preface (H. Timmerman). Receptors - from dream to reality (E.J. Ariens). Receptor-membrane interactions: A new focus for structure-activity relationships (M.D. Hollenberg). Structure-activity relationships: Pharmacology and function of melatonin receptors (M.L. Dubocovich). Structure-activity relationships of antagonists acting selectively at muscarinic receptor subtypes (C. Melchiorre et al.). Rational approaches to enzyme inhibitors: New HMG-CoA reductase inhibitors (E. Baader et al.). Peptide engineering: Design of biologically active peptides under conformational control (H. Kessler). Peptide-drugs: New developments, progress and limitations (W. Bauer). Encephalinase inhibitors: ANF-like activity and potential clinical applications (J.C. Schwartz et al.). Tropical diseases, recent drug developments with special emphasis on antimalarial and antileprosy drugs (J.K. Seydel et al.). New developments in anti-AIDS drug research (E. De Clercq). Therapeutic possibilities with 5-HT 3 receptor antagonists (M.B. Tyers et al.). The atrial natriuretic factor: A new hormonal system (G. Thibault). Special features of the development of biological response modifiers - for example rIL-2 (C.R. Franks, P.A. Palmer). Contribution of positron emission tomography to drug investigations (B. Maziere). Structure-toxicity relationships: What can we learn from some newer drugs? (S.D. Nelson). Identification of toxicophoric groups: The case of halogenated benzenes (P.J. van Bladeren, C. den Besten). QSAR approaches in molecular toxicology (H. van de Waterbeemd). Molecular mechanisms in toxicology and drug design (N.P.E. Vermeulen et al.). Receptor function in free radical mediated pathologies (A. Bast, G.R.M.M. Haenen). Site-specific drugs and delivery systems: Rationale, potential and limitations (E. Tomlinson). Design of cell-specific drug targeting preparations for the liver: Where cell biology and medicinal chemistry meet (D.K.F. Meijer et al.). Drug targeting with immunoliposomes (G. Storm et al.). Comparison of antitumour effects of ricin A-chain IgG and Fab' immunotoxins for the treatment of Hodgkin's disease (A. Engert et al.). Advantages and limitations of applied biocatalysis (E.M. Meijer et al.). Biotechnology in the flavour and fragrance industry (P.S.J. Cheetham). Innovative approaches to intermediates with biocatalysis: A new process for S-2-chloropropanoic acid (S.C. Taylor). Microbes in organic synthesis
- a versatile approach (H.J. Kooreman). Lessons from the clinic (P. Janssen). Subject index.
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