The Search for antiviral drugs : case histories from concept to clinic
著者
書誌事項
The Search for antiviral drugs : case histories from concept to clinic
Birkhäuser, c1993
- Boston
- Berlin
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
From the earliest days of antiviral research, which produced the nucleoside analogs for the effective treatment of viral infections, to the latest antiviral strategies in preclinical testing, such as HIV-TAT antagonists, this book examines the pitfalls and successes of large-scale drug research. Readers should enjoy the behind-the-scenes look into the ways in which projects and programmes get started, including the development of AZT, as well as the strategies and problems faced by biomedical researchers looking for answers to Herpes, AIDS and the common cold.
目次
- The first effective antiviral, Herbert E. Kaufman
- the discovery and development of Zidovudine as the cornerstone of therapy to control human immunodeficiency virus infection, Kathryn H. Pattishall
- discovery of Nevirapine, a nonnucleoside inhibitor of HIV-1 reverse transcriptase, Julian Adams and Vincent J. Merluzzi
- discovery of TIBO, a new family of HIV-1 specific reverse transcriptase inhibitors, Rudi Pauwels
- discovery and development of 2-Pyridinone HIV-1 reverse transcriptase inhibitors, Mark E. Goldman
- discovery and development of the HIV proteinase inhibitor, Ro 31-8959, Noel A. Roberts and Sally Redshaw
- a new approach to antiviral chemotherapy - intervention in viral gene expression by HIV Tat antagonists, Ming-Chu Hsu and Steve Tam
- discovery of Pirodavir, a broad-spectrum inhibitor of Rhinoviruses, Koen Andries
- sICAM-1 as a receptor antagonist for Rhinoviruses - a model system of adhesion molecules as cell receptors for viruses, Steven D. Marlin
- inactivation of Herpes Simplex Virus Ribonucleotide Reductase by Subunit Association Inhibitors - a potential antiviral strategy, Michel Liuzzi and Robert Deziel.
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