DNA and free radicals
著者
書誌事項
DNA and free radicals
Ellis Horwood, c1993
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
This book gives a comprehensive account of the input of biologists and medical scientists towards the understanding of the role of oxidative stress and DNA damage in human diseases. Written by renowned experts in the field, the book emphasizes the role played by free radicals, promotes understanding of the fundamental mechanisms underlying the pathology of human diseases, shows how DNA is an important target in cellular damage, and outlines the pioneering studies relating to the chemistry of DNA damage.
目次
- Oxidants are major contributors to cancer and aging. Part 1 Chemistry and measurement of damage to DNA by reactive oxygen species: chemistry of free radical damage to DNA and nucleoproteins
- DNA damage induced by photosensitization
- oxidative damage - meaning and measurement. Part 2 Mechanism of DNA damage by oxidative stress: hydrogen peroxide and DNA damage
- oxidative stress and calcium homeostasis
- lipid peroxidation and cancer
- the role of organic peroxyl radicals in carcinogenesis. Part 3 Consequences of oxidative DNA damage: enzymes that repair oxidative damage to DNA
- sex as a response to oxidative DNA damage
- oxidative stress and cell proliferation "in vitro"
- ornithine decarboxylase and tumour promotion - a role for oxidants. Part 4 Pro-oxidants and DNA damage: redox cycling drugs and DNA damage
- role of reactive oxygen species in the mutagenicity of complex mixtures of plant origin
- mineral fibres, cigarette smoke and oxidative DNA damage
- use of DNA damage as a measure of pro-oxidant actions of antioxidant food additives and nutrient components.
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