Carbohydrates : synthetic methods and applications in medicinal chemistry

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Bibliographic Information

Carbohydrates : synthetic methods and applications in medicinal chemistry

edited by Haruo Ogura, Akira Hasegawa, and Tetsuo Suami

Kodansha , VCH, c1992

  • : gw
  • : us
  • : ja

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Includes bibliographical references and index

Description and Table of Contents

Description

Carbohydrates play an increasingly important role in medicinal and synthetic organic chemistry. Stimulating and timely, this collection of essays introduces the reader to synthetic applications and biological functions of carbohydrates, thus reflecting the state of the art of the subject. The book is intended for researchers in synthetic organic chemistry and medicinal chemistry, who will use it as a reference work as well as a source of new ideas and perspectives.

Table of Contents

  • Part 1 Synthetic methods of carbohydrate by chemicals: efficient reaction channels from mono-and disaccharides to enaniopure building blocks and exploitation of their application profiles, F.W. Lichtenthaler
  • stereocontrolled synthesis of C-glycosides, S. Czernecki
  • glycals in palladium-mediated C-glycosal bond formation, G.D. Davis Jr
  • new apsects of glycosylation reactions, Richard R. Schmidt
  • radical functionalization of the anomeric centre of carbohydrates and synthetic applications, G. Decostes
  • improvements in the synthesis of trehalose-based bacterial lipids, Anderson A.K. Datta et al
  • from sugars to morpholines, spiro-acetals and alkaloids, L. Hough and A.C. Richardson
  • synthesis of antibiotic hygromycon A and its derivatives, Noritaka Chida and Seiichiro Ogawa
  • synthesis of biologically active pseudo-oligosaccharides, T. Suami. Part 2 Synthetic methods of carbohydrate by enzyme: combined classical and chemoenzymatic glycosylations, R. Stiller and J. Thiem
  • synthesis of oligosaccharides related to plant, vertebrate and bacterial, cell-wall glycans, V. Pozsgay
  • malto-oligosaccharides as starting materials for synthesis of bioactive compounds, H. Kuzuhara and N. Sakairi. Part 3 Synthetic and biological studies on sialic acid: systematic synthesis of gangliosides toward the elucidation and biomedical application of their biological functions, A. Hasegawa and M. Kiso
  • synthesis of biologically active sialo-compunds, K. Ikeda and K. Achiwa
  • sialic acid derivatives as glyco-lipoid, H. Ogura
  • synthesis of sialic acid analogues and their behaviour toward the enzymes of the sialic acid metabolism as well as the hemagglutinin X-31 of influenza A virus, A. Zbiral
  • sialic acids regulate cellular and molecular recognition, R. Schauer. Part 4 Functional and biological studies of glycoconjugate: new strategies in the synthesis of beta-D-galacto-oligosaccharides - a synthetic heptasaccharide reveals the "groove-binding" character of a monoclonal antibody, T. Zieglaer et al
  • cell surface carbohydrates - their involvement in cell adhesion
  • chemical and enzymatic methods for the depolymerization and modification of heparin, R.J. Lindhardt.

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